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Proteintech
SPAG5 Polyclonal Antibody
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Product Details
14726-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPAG5 Fusion Protein Ag6485 (844-1193 aa encoded by BC000322)
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to SPAG5.
Immunogen sequence: TVENLTAKL ASTIADNQEQ DLEKTRQYSQ KLGLLTEQLQ SLTLFLQTKL KEKTEQETLL LSTACPPTQE HPLPNDRTFL GSILTAVADE EPESTPVPLL GSDKSAFTRV ASMVSLQPAE TPGMEESLAE MSIMTTELQS LCSLLQESKE EAIRTLQRKI CELQARLQAQ EEQHQEVQKA KEADIEKLNQ ALCLRYKNEK ELQEVIQQQN EKILEQIDKS GELISLREEV THLTRSLRRA ETETKVLQEA LAGQLDSNCQ PMATNWIQEK VWLSQEVDKL RVMFLEMKNE KEKLMIKFQS HRNILEENLR RSDKELEKLD DIVQHIYKTL LSIPEVVRGC KELQGLLEFL S (844-1193 aa encoded by BC000322)
Target Information
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon and thymus. Localized specifically to spindle poles during prophase and throughout the spindle during metaphase and anaphase, SPAG5 is essential for proper spindle formation and is thought to be involved in the dynamic and functional regulation of mitotic spindles. Additionally, SPAG5 plays a role in sister chromatid cohesion and subsequent chromatid separation and, via its association with chromatids, is an important regulator of chromosome integrity. SPAG5 has a long stalk and a globular head domain through which if forms a homodimer that is characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Astrin; Deepest; MAP126; Mastrin; microtubule-associated protein; mitotic spindle associated protein p126; mitotic spindle coiled-coil related protein; Mitotic spindle-associated protein p126; Sperm-associated antigen 5
Gene Aliases: AI874642; D11Bhm180e; DEEPEST; hMAP126; MAP126; Mastrin; S17; SPAG5
UniProt ID: (Human) Q96R06, (Mouse) Q7TME2
Entrez Gene ID: (Human) 10615, (Mouse) 54141
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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