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Bethyl Laboratories
SPAK Polyclonal Antibody
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Product Details
A302-465A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 375 and 425 of Human STE20/SPS1-related proline-alanine-rich protein kinase.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
STK39 (STLK3) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress. STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DCHT; DKFZp686K05124; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine-threonine kinase; serine/threonine kinase homolog; Serine/threonine-protein kinase 39; small intestine SPAK-like kinase; Ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1 homolog; STE20/SPS1-related proline-alanine-rich protein kinase
Gene Aliases: DCHT; PASK; SPAK; STK39
UniProt ID: (Human) Q9UEW8
Entrez Gene ID: (Human) 27347
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
potassium channel inhibitor activity
protein kinase binding
ion channel binding
ion channel regulator activity
protein serine kinase activity
transporter activator activity
transporter inhibitor activity
response to dietary excess
protein phosphorylation
cell volume homeostasis
inflammatory response
signal transduction
regulation of blood pressure
positive regulation of T cell chemotaxis
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cellular chloride ion homeostasis
negative regulation of transmembrane transport
intracellular signal transduction
sodium ion transmembrane transport
cellular response to potassium ion
maintenance of lens transparency
chemokine (C-X-C motif) ligand 12 signaling pathway
macrophage activation
positive regulation of potassium ion transport
protein autophosphorylation
regulation of inflammatory response
ion homeostasis
renal sodium ion absorption
cellular hyperosmotic response
cellular hypotonic response
potassium ion transmembrane transport
negative regulation of pancreatic juice secretion
positive regulation of p38MAPK cascade
negative regulation of potassium ion transmembrane transport
negative regulation of sodium ion transmembrane transport
positive regulation of potassium ion import
positive regulation of sodium ion import across plasma membrane
response to aldosterone
regulation of cation transmembrane transport
cellular response to chemokine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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