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Proteintech
SPDEF Polyclonal Antibody
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Product Details
11467-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPDEF Fusion Protein Ag2020 (1-335 aa encoded by BC021299)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGSASPGLS SVSPSHLLLP PDTVSRTGLE KAAAGAVGLE RRDWSPSPPA TPEQGLSAFY LSYFDMLYPE DSSWAAKAPG ASSREEPPEE PEQCPVIDSQ APAGSLDLVP GGLTLEEHSL EQVQSMVVGE VLKDIETACK LLNITADPMD WSPSNVQKWL LWTEHQYRLP PMGKAFQELA GKELCAMSEE QFRQRSPLGG DVLHAHLDIW KSAAWMKERT SPGAIHYCAS TSEESWTDSE VDSSCSGQPI HLWQFLKELL LKPHSYGRFI RWLNKEKGIF KIEDSAQVAR LWGIRKNRPA MNYDKLSRSI RQYYKKGIIR KPDISQRLVY QFVHPI (1-335 aa encoded by B C021299)
Target Information
PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Prostate epithelium-specific Ets transcription factor; prostate specific ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; SAM pointed domain-containing Ets transcription factor
Gene Aliases: bA375E1.3; PDEF; PSE; SPDEF
UniProt ID: (Human) O95238, (Mouse) Q9WTP3
Entrez Gene ID: (Human) 25803, (Mouse) 30051, (Rat) 689210
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
negative regulation of cell fate commitment
positive regulation of cell fate commitment
cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
lung goblet cell differentiation
intestinal epithelial cell development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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