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Immunogen sequence: MGSASPGLS SVSPSHLLLP PDTVSRTGLE KAAAGAVGLE RRDWSPSPPA TPEQGLSAFY LSYFDMLYPE DSSWAAKAPG ASSREEPPEE PEQCPVIDSQ APAGSLDLVP GGLTLEEHSL EQVQSMVVGE VLKDIETACK LLNITADPMD WSPSNVQKWL LWTEHQYRLP PMGKAFQELA GKELCAMSEE QFRQRSPLGG DVLHAHLDIW KSAAWMKERT SPGAIHYCAS TSEESWTDSE VDSSCSGQPI HLWQFLKELL LKPHSYGRFI RWLNKEKGIF KIEDSAQVAR LWGIRKNRPA MNYDKLSRSI RQYYKKGIIR KPDISQRLVY QFVHPI (1-335 aa encoded by B C021299)
PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
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Protein Aliases: Prostate epithelium-specific Ets transcription factor; prostate specific ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; SAM pointed domain-containing Ets transcription factor
Gene Aliases: bA375E1.3; PDEF; PSE; SPDEF
Molecular Function: winged helix/forkhead transcription factor