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Invitrogen
SPEN Polyclonal Antibody
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Product Details
PA5-65605
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human SPEN. Recombinant protein control fragment (Product #RP-106268).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GEAVENQEVQS KKPIPSKPQL KQLQVLDDQG PEREDVRKNY CSLRDETPER KSGQEKSHSV NTEEKIGIDI DHTQSYRKQM EQSRRKQQME MEIAKSEKFG SPKKDVDEYE RRSLVHEVGK PPQDVTDDSP PSK
Highest antigen sequence identity to the following orthologs - mouse 78%, rat 82%.
Target Information
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Msx2 interacting nuclear target (MINT) homolog; Msx2-interacting protein; nuclear receptor transcription cofactor; SMART/HDAC1-associated repressor protein; SPEN homolog; spen homolog, transcriptional regulator; unnamed protein product
Gene Aliases: HIAA0929; KIAA0929; MINT; RATARS; RBM15C; SHARP; SPEN
UniProt ID: (Human) Q96T58
Entrez Gene ID: (Human) 23013
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
chromatin silencing by small RNA
negative regulation of transcription, DNA-templated
positive regulation of neurogenesis
random inactivation of X chromosome
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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