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Proteintech
SPG11 Polyclonal Antibody
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Product Details
16555-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPG11 Fusion Protein Ag9769 (133-482 aa encoded by BC024161)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TLVGMKLLD KISSVPHGEL SCTTELLILA HHCFTLTCHM EGIIRVLQAA HMLTDNHLAP SEEYGLVVRL LTGIGRYNEM TYIFDLLHKK HYFEVLMRKK LDPSGTLKTA LLDYIKRCRP GDSEKHNMIA LCFSMCREIG ENHEAAARIQ LKLIESQPWE DSLKDGHQLK QLLLKALTLM LDAAESYAKD SCVRQAQHCQ RLTKLITLQI HFLNTGQNTM LINLGRHKLM DCILALPRFY QASIVAEAYD FVPDWAEILY QQVILKGDFN YLEEFKQQRL LKSSIFEEIS KKYKQHQPTD MVMENLKKLL TYCEDVYLYY KLAYEHKFYE IVNVLLKDPQ TGCCLKDMLA G (133-482 aa encoded by BC024161)
Target Information
Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene. Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: amyotrophic lateral sclerosis 5; Colorectal carcinoma-associated protein; spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11 protein; Spastic paraplegia 11 protein homolog; Spatacsin; SPG11, spatacsin vesicle trafficking associated; unnamed protein product
Gene Aliases: 6030465E24Rik; A330015I11; ALS5; C530005A01Rik; CMT2X; KIAA1840; RGD1562529; SPG11
UniProt ID: (Human) Q96JI7, (Mouse) Q3UHA3
Entrez Gene ID: (Human) 80208, (Mouse) 214585, (Rat) 311372
protein import into nucleus
intracellular protein transport
lysosome organization
chemical synaptic transmission
axonogenesis
neuromuscular junction development
memory
axo-dendritic transport
protein localization
corticospinal tract morphogenesis
protein catabolic process
cholesterol efflux
vesicle transport along microtubule
synaptic vesicle transport
axon extension
skeletal muscle fiber development
neuron apoptotic process
localization within membrane
motor behavior
phagosome-lysosome fusion involved in apoptotic cell clearance
walking behavior
motor neuron apoptotic process
autophagosome organization
regulation of store-operated calcium entry
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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