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Abnova
SPG7 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
SPG7 Antibody (H00006687-D01P) in WB
Western Blot analysis of SPG7 expression in transfected 293T cell line (H00006687-T01) by SPG7 MaxPab polyclonal antibody.
Lane 1: SPG7 transfected lysate(88.20 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SPG7 transfected lysate(88.20 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00006687-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPG7 (NP_003110.1, 1 a.a. approximately 795 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAVLLLLLRA LRRGPGPGPR PLWGPGPAWS PGFPARPGRG RPYMASRPPG DLAEAGGRAL QSLQLRLLTP TFEGINGLLL KQHLVQNPVR LWQLLGGTFY FNTSRLKQKN KEKDKSKGKA PEEDEEERRR RERDDQMYRE RLRTLLVIAV VMSLLNALST SGGSISWNDF VHEMLAKGEV QRVQVVPESD VVEVYLHPGA VVFGRPRLAL MYRMQVANID KFEEKLRAAE DELNIEAKDR IPVSYKRTGF FGNALYSVGM TAVGLAILWY VFRLAGMTGR EGGFSAFNQL KMARFTIVDG KMGKGVSFKD VAGMHEAKLE VREFVDYLKS PERFLQLGAK VPKGALLLGP PGCGKTLLAK AVATEAQVPF LAMAGPEFVE VIGGLGAARV RSLFKEARAR APCIVYIDEI DAVGKKRSTT MSGFSNTEEE QTLNQLLVEM DGMGTTDHVI VLASTNRADI LDGALMRPGR LDRHVFIDLP TLQERREIFE QHLKSLKLTQ SSTFYSQRLA ELTPGFSGAD IANICNEAAL HAAREGHTSV HTLNFEYAVE RVLAGTAKKS KILSKEEQKV VAFHESGHAL VGWMLEHTEA VMKVSITPRT NAALGFAQML PRDQHLFTKE QLFERMCMAL GGRASEALSF NEVTSGAQDD LRKVTRIAYS MVKQFGMAPG IGPISFPEAQ EGLMGIGRRP FSQGLQQMMD HEARLLVAKA YRHTEKVLQD NLDKLQALAN ALLEKEVINY EDIEALIGPP PHGPKKMIAP QRWIDAQREK QDLGEEETEE TQQPPLGGEE PTWPK
Target Information
This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell matrix adhesion regulator; Mitochondrial inner membrane m-AAA protease component paraplegin; Paraplegin; spastic paraplegia 7 (pure and complicated autosomal recessive); Spastic paraplegia 7 protein; SPG7, paraplegin matrix AAA peptidase subunit; unnamed protein product
Gene Aliases: CAR; CMAR; PGN; SPG5C; SPG7
UniProt ID: (Human) Q9UQ90
Entrez Gene ID: (Human) 6687
proteolysis
mitochondrion organization
nervous system development
anterograde axonal transport
mitochondrial protein processing
calcium ion transmembrane import into mitochondrion
regulation of mitochondrial membrane permeability
regulation of calcium import into the mitochondrion
mitochondrial outer membrane permeabilization involved in programmed cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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