Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
10107-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPIN2B Fusion Protein Ag0157 (35-223 aa encoded by BC000044)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KKQRGRPSS QPRRNIVGCR ISHGWKEGDE PITQWKGTVL DQVPINPSLY LVKYDGIDCV YGLELHRDER VLSLKILSDR VASSHISDAN LANTIIGKAV EHMFEGEHGS KDEWRGMVLA QAPIMKAWFY ITYEKDPVLY MYQLLDDYKE GDLRIMPESS ESPPTEREPG GVVDGLIGKH VEYTKEDGSK (35-223 aa encoded by BC000044)
Target Information
Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: SPIN-2; Spindlin 2B; spindlin family, member 2; spindlin family, member 2 duplicate; spindlin family, member 2B; spindlin-2; Spindlin-2B; Spindlin-2C; spindlin-like protein 2; Spindlin-like protein 2B; Spindlin-like protein 2C; telomeric SPIN2 copy
Gene Aliases: BC068162; dJ323P24.2; SPIN-2; SPIN-2B; SPIN-2C; SPIN2; SPIN2_duplicate; SPIN2B; Spin2c; TDRD26
UniProt ID: (Human) Q9BPZ2, (Mouse) Q6NVE3
Entrez Gene ID: (Human) 474343, (Mouse) 278240
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support