Immunogen sequence: LEEIKAERKL RPVSPEEIRR SRLDVTTPES TKNLVESSMV NGGLTSQTKE NGLSTSQQVP AQRKKLLRAP TLAELDSSES EEETLHK
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 83%.
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KIAA1135; Protein spire homolog 1; Spir-1; SPIR1; spire actin nucleation factor 1; spire family actin nucleation factor 1; spire homolog 1; spire-type actin nucleation factor 1; SPIRE1
Gene Aliases: KIAA1135; Spir-1; SPIR1; SPIRE1
UniProt ID: (Human) Q08AE8
Entrez Gene ID: (Human) 56907