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Proteintech
SPIRE2 Polyclonal Antibody
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Product Details
17757-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPIRE2 Fusion Protein Ag12117 (318-666 aa encoded by BC111030)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IRSRPPLKQ VSERRLRPLP PKQRSLHEKI LEEIKQERRL RPVRGEGWAA RGFGSLPCIL NACSGDAKST SCINLSVTDA GGSAQRPRPR VLLKAPTLAE MEEMNTSEEE ESPCGEVTLK RDRSFSEHDL AQLRSEVASG LQSATHPPGG TEPPRPRAGS AHVWRPGSRD QGTCPASVSD PSHPLLSNRG SSGDRPEASM TPDAKHLWLE FSHPVESLAL TVEEVMDVRR VLVKAEMEKF LQNKELFSSL KKGKICCCCR AKFPLFSWPP SCLFCKRSLQ GPQWQSVEEA FPHIYSHGCV LKDVCSECTS FVADVVRSSR KSVDVLNTTP RRSRQTQSLY IPNTRTLDFK (318-666 aa encoded by BC111030)
Target Information
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein spire homolog 2; Spir-2; spire actin nucleation factor 2; spire family actin nucleation factor 2; spire homolog 2; unnamed protein product
Gene Aliases: BC026502; KIAA1832; Spir-2; SPIR2; SPIRE2
UniProt ID: (Human) Q8WWL2, (Mouse) Q8K1S6
Entrez Gene ID: (Human) 84501, (Rat) 307925, (Mouse) 234857
protein transport
vesicle-mediated transport
actin cytoskeleton organization
cleavage furrow formation
polar body extrusion after meiotic divisions
actin nucleation
intracellular transport
Golgi vesicle transport
establishment of meiotic spindle localization
actin filament network formation
formin-nucleated actin cable assembly
positive regulation of double-strand break repair
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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