Immunogen sequence: RAQLHVQGLL HEAGSTDDRI VVPQRGRSTR VPVASVLI
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 84%.
SPINSTER, also known as SPNS1 or SPIN1, is a 528 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and belongs to the spinster subfamily of the major facilitator superfamily. SPINSTER interacts with Bcl-x and Bcl-2 and, via this interaction, is thought to be involved in necrotic or autophagic cell death. The related protein SPNS2 is critical for the normal lymphocyte localization and mammalian immune system function.
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Protein Aliases: HSpin1; Protein spinster homolog 1; spinster homolog 1; Spinster-like protein 1; SPNS sphingolipid transporter 1 (putative)
Gene Aliases: HSpin1; LAT; nrs; PP2030; PP20300; SPIN1; SPINL; SPNS1
UniProt ID: (Human) Q9H2V7
Entrez Gene ID: (Human) 83985
Molecular Function: transporter