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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 138 and 396 of Human SPO11|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30549 targets SPO11 in WB applications and shows reactivity with Human samples.
The PA5-30549 immunogen is recombinant fragment corresponding to a region within amino acids 138 and 396 of Human SPO11.
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cancer/testis antigen 35; CT35; Meiotic recombination protein SPO11; spermatogenesis associated 43; SPO11 meiotic protein covalently bound to DSB homolog
CT35; SPATA43; SPO11; TOPVIA