Product References
TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks.
Nature communications
Ma J,Zhou Y,Pan P,Yu H,Wang Z,Li LL,Wang B,Yan Y,Pan Y,Ye Q,Liu T,Feng X,Xu S,Wang K,Wang X,Jian Y,Ma B,Fan Y,Gao Y,Huang H,Li L
Fri Mar 31 00:00:00 UTC 2023
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.
Oncogene
Zhou P,Chang WY,Gong DA,Huang LY,Liu R,Liu Y,Xia J,Wang K,Tang N,Huang AL
Wed Mar 01 00:00:00 UTC 2023
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.
Oncogene
Zhou P,Chang WY,Gong DA,Huang LY,Liu R,Liu Y,Xia J,Wang K,Tang N,Huang AL
Wed Mar 01 00:00:00 UTC 2023
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.
Oncogene
Zhou P,Chang WY,Gong DA,Huang LY,Liu R,Liu Y,Xia J,Wang K,Tang N,Huang AL
Wed Mar 01 00:00:00 UTC 2023
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.
Oncogene
Zhou P,Chang WY,Gong DA,Huang LY,Liu R,Liu Y,Xia J,Wang K,Tang N,Huang AL
Wed Mar 01 00:00:00 UTC 2023
Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.
The Journal of clinical investigation
Ding L,Chen X,Zhang W,Dai X,Guo H,Pan X,Xu Y,Feng J,Yuan M,Gao X,Wang J,Xu X,Li S,Wu H,Cao J,He Q,Yang B
Tue Jan 03 00:00:00 UTC 2023
Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.
The Journal of clinical investigation
Ding L,Chen X,Zhang W,Dai X,Guo H,Pan X,Xu Y,Feng J,Yuan M,Gao X,Wang J,Xu X,Li S,Wu H,Cao J,He Q,Yang B
Tue Jan 03 00:00:00 UTC 2023
Additive Effect of CD73 Inhibitor in Colorectal Cancer Treatment With CDK4/6 Inhibitor Through Regulation of PD-L1.
Cellular and molecular gastroenterology and hepatology
Noh JY,Lee IP,Han NR,Kim M,Min YK,Lee SY,Yun SH,Kim SI,Park T,Chung H,Park D,Lee CH
Mon Sep 26 00:00:00 UTC 2022
A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.
Science advances
Tawaratsumida K,Redecke V,Wu R,Kuriakose J,Bouchard JJ,Mittag T,Lohman BK,Mishra A,High AA,Häcker H
Fri Jul 08 00:00:00 UTC 2022
A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.
Science advances
Tawaratsumida K,Redecke V,Wu R,Kuriakose J,Bouchard JJ,Mittag T,Lohman BK,Mishra A,High AA,Häcker H
Fri Jul 08 00:00:00 UTC 2022
A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.
Science advances
Tawaratsumida K,Redecke V,Wu R,Kuriakose J,Bouchard JJ,Mittag T,Lohman BK,Mishra A,High AA,Häcker H
Fri Jul 08 00:00:00 UTC 2022
A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.
Science advances
Tawaratsumida K,Redecke V,Wu R,Kuriakose J,Bouchard JJ,Mittag T,Lohman BK,Mishra A,High AA,Häcker H
Fri Jul 08 00:00:00 UTC 2022
CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein.
Journal for immunotherapy of cancer
Dong M,Qian M,Ruan Z
Sat Oct 01 00:00:00 UTC 2022
CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein.
Journal for immunotherapy of cancer
Dong M,Qian M,Ruan Z
Sat Oct 01 00:00:00 UTC 2022
Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function.
Cancer research
Zhao X,Wei Y,Chu YY,Li Y,Hsu JM,Jiang Z,Liu C,Hsu JL,Chang WC,Yang R,Chan LC,Qu J,Zhang S,Ying H,Yu D,Hung MC
Mon Jun 06 00:00:00 UTC 2022
Loss of Speckle-Type POZ Protein Promotes Prostate Cancer Cell Migration and Invasion Through Upregulation of MCP-1.
Medical science monitor : international medical journal of experimental and clinical research
Shi J,Cao J,Lu X,Fan L,Guo H,Fu J
Mon Apr 19 00:00:00 UTC 2021
SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Su S,Chen J,Jiang Y,Wang Y,Vital T,Zhang J,Laggner C,Nguyen KT,Zhu Z,Prevatte AW,Barker NK,Herring LE,Davis IJ,Liu P
Thu Jul 01 00:00:00 UTC 2021
SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.
Molecular cancer
Jiang Q,Zheng N,Bu L,Zhang X,Zhang X,Wu Y,Su Y,Wang L,Zhang X,Ren S,Dai X,Wu D,Xie W,Wei W,Zhu Y,Guo J
Thu Aug 05 00:00:00 UTC 2021
G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer.
Nature communications
Mukhopadhyay C,Yang C,Xu L,Liu D,Wang Y,Huang D,Deonarine LD,Cyrta J,Davicioni E,Sboner A,Robinson BD,Chinnaiyan AM,Rubin MA,Barbieri CE,Zhou P
Thu Nov 18 00:00:00 UTC 2021
G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer.
Nature communications
Mukhopadhyay C,Yang C,Xu L,Liu D,Wang Y,Huang D,Deonarine LD,Cyrta J,Davicioni E,Sboner A,Robinson BD,Chinnaiyan AM,Rubin MA,Barbieri CE,Zhou P
Thu Nov 18 00:00:00 UTC 2021
G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer.
Nature communications
Mukhopadhyay C,Yang C,Xu L,Liu D,Wang Y,Huang D,Deonarine LD,Cyrta J,Davicioni E,Sboner A,Robinson BD,Chinnaiyan AM,Rubin MA,Barbieri CE,Zhou P
Thu Nov 18 00:00:00 UTC 2021
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Nature communications
Ma J,Shi Q,Cui G,Sheng H,Botuyan MV,Zhou Y,Yan Y,He Y,Wang L,Wang Y,Mer G,Ye D,Wang C,Huang H
Fri Oct 01 00:00:00 UTC 2021
Genetic fusions favor tumorigenesis through degron loss in oncogenes.
Nature communications
Liu J,Tokheim C,Lee JD,Gan W,North BJ,Liu XS,Pandolfi PP,Wei W
Thu Nov 18 00:00:00 UTC 2021
Genetic fusions favor tumorigenesis through degron loss in oncogenes.
Nature communications
Liu J,Tokheim C,Lee JD,Gan W,North BJ,Liu XS,Pandolfi PP,Wei W
Thu Nov 18 00:00:00 UTC 2021
ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Science advances
Wang D,Ma J,Botuyan MV,Cui G,Yan Y,Ding D,Zhou Y,Krueger EW,Pei J,Wu X,Wang L,Pei H,McNiven MA,Ye D,Mer G,Huang H
Tue Jun 01 00:00:00 UTC 2021
SPOP mutation induces DNA methylation via stabilizing GLP/G9a.
Nature communications
Zhang J,Gao K,Xie H,Wang D,Zhang P,Wei T,Yan Y,Pan Y,Ye W,Chen H,Shi Q,Li Y,Zhao SM,Hou X,Weroha SJ,Wang Y,Zhang J,Karnes RJ,He HH,Wang L,Wang C,Huang H
Wed Sep 29 00:00:00 UTC 2021
Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis.
Cancer cell international
He Y,Chen J,Peng X,Xia Y,Su Y
Sat Nov 27 00:00:00 UTC 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
Wed Jul 21 00:00:00 UTC 2021
Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.
Cell biology international
Yuan D,Yang Z,Chen Y,Li S,Tan B,Yu Q
Mon Mar 01 00:00:00 UTC 2021
Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.
Cell biology international
Yuan D,Yang Z,Chen Y,Li S,Tan B,Yu Q
Mon Mar 01 00:00:00 UTC 2021
Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang H,Xia Y,Wang F,Luo M,Yang K,Liang S,An S,Wu S,Yang C,Chen D,Xu M,Cai M,To KKW,Fu L
Sat May 01 00:00:00 UTC 2021
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway.
Neoplasia (New York, N.Y.)
Luo Z,Wang J,Zhu Y,Sun X,He C,Cai M,Ma J,Wang Y,Han S
Fri Oct 01 00:00:00 UTC 2021
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway.
Neoplasia (New York, N.Y.)
Luo Z,Wang J,Zhu Y,Sun X,He C,Cai M,Ma J,Wang Y,Han S
Fri Oct 01 00:00:00 UTC 2021
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Clinical and translational medicine
Zhang L,Wang X,Li Y,Han J,Gao X,Li S,Wang F
Wed Sep 01 00:00:00 UTC 2021
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Clinical and translational medicine
Zhang L,Wang X,Li Y,Han J,Gao X,Li S,Wang F
Wed Sep 01 00:00:00 UTC 2021
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Clinical and translational medicine
Zhang L,Wang X,Li Y,Han J,Gao X,Li S,Wang F
Wed Sep 01 00:00:00 UTC 2021
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Clinical and translational medicine
Zhang L,Wang X,Li Y,Han J,Gao X,Li S,Wang F
Wed Sep 01 00:00:00 UTC 2021
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Clinical and translational medicine
Zhang L,Wang X,Li Y,Han J,Gao X,Li S,Wang F
Wed Sep 01 00:00:00 UTC 2021
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Clinical and translational medicine
Zhang L,Wang X,Li Y,Han J,Gao X,Li S,Wang F
Wed Sep 01 00:00:00 UTC 2021
SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.
Cellular & molecular immunology
Hu YH,Wang Y,Wang F,Dong YM,Jiang WL,Wang YP,Zhong X,Ma LX
Thu Jul 01 00:00:00 UTC 2021
The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.
Proceedings of the National Academy of Sciences of the United States of America
Snoznik C,Medvedeva V,Mojsilovic-Petrovic J,Rudich P,Oosten J,Kalb RG,Lamitina T
Tue Oct 05 00:00:00 UTC 2021
Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression.
FEBS letters
Ghosh C,Xing Y,Li S,Hoyle RG,Sun M,Li J,Sun Y
Fri Oct 01 00:00:00 UTC 2021
SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.
Molecular biology of the cell
Watanabe R,Maekawa M,Hieda M,Taguchi T,Miura N,Kikugawa T,Saika T,Higashiyama S
Sun Mar 15 00:00:00 UTC 2020
SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.
Molecular biology of the cell
Watanabe R,Maekawa M,Hieda M,Taguchi T,Miura N,Kikugawa T,Saika T,Higashiyama S
Sun Mar 15 00:00:00 UTC 2020
ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.
Cell research
Li K,Wu JL,Qin B,Fan Z,Tang Q,Lu W,Zhang H,Xing F,Meng M,Zou S,Wei W,Chen H,Cai J,Wang H,Zhang H,Cai J,Fang L,Bian X,Chen C,Lan P,Ghesquière B,Fang L,Lee MH
Sat Feb 01 00:00:00 UTC 2020
Snail promotes prostate cancer migration by facilitating SPOP ubiquitination and degradation.
Biochemical and biophysical research communications
Lv W,Huan M,Yang W,Gao Y,Wang K,Xu S,Zhang M,Ma J,Wang X,Chen Y,Li L
Thu Aug 27 00:00:00 UTC 2020
SPOP promotes ubiquitination and degradation of LATS1 to enhance kidney cancer progression.
EBioMedicine
Wang L,Lin M,Chu M,Liu Y,Ma J,He Y,Wang ZW
Mon Jun 01 00:00:00 UTC 2020
SPOP promotes ubiquitination and degradation of LATS1 to enhance kidney cancer progression.
EBioMedicine
Wang L,Lin M,Chu M,Liu Y,Ma J,He Y,Wang ZW
Mon Jun 01 00:00:00 UTC 2020
BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1.
Cancer research
Zong D,Gu J,Cavalcante GC,Yao W,Zhang G,Wang S,Owonikoko TK,He X,Sun SY
Mon Jun 01 00:00:00 UTC 2020
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Molecular therapy oncolytics
He W,Zhang J,Liu B,Liu X,Liu G,Xie L,He J,Wei M,Li K,Ma J,Dong R,Ma D,Dong K,Ye M
Wed Dec 16 00:00:00 UTC 2020
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Molecular therapy oncolytics
He W,Zhang J,Liu B,Liu X,Liu G,Xie L,He J,Wei M,Li K,Ma J,Dong R,Ma D,Dong K,Ye M
Wed Dec 16 00:00:00 UTC 2020
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Molecular therapy oncolytics
He W,Zhang J,Liu B,Liu X,Liu G,Xie L,He J,Wei M,Li K,Ma J,Dong R,Ma D,Dong K,Ye M
Wed Dec 16 00:00:00 UTC 2020
DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1.
Molecular cell
Hong Z,Zhang W,Ding D,Huang Z,Yan Y,Cao W,Pan Y,Hou X,Weroha SJ,Karnes RJ,Wang D,Wu Q,Wu D,Huang H
Thu Sep 17 00:00:00 UTC 2020
AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.
Developmental cell
Wang X,Jin J,Wan F,Zhao L,Chu H,Chen C,Liao G,Liu J,Yu Y,Teng H,Fang L,Jiang C,Pan W,Xie X,Li J,Lu X,Jiang X,Ge X,Ye D,Wang P
Mon Feb 11 00:00:00 UTC 2019
AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.
Developmental cell
Wang X,Jin J,Wan F,Zhao L,Chu H,Chen C,Liao G,Liu J,Yu Y,Teng H,Fang L,Jiang C,Pan W,Xie X,Li J,Lu X,Jiang X,Ge X,Ye D,Wang P
Mon Feb 11 00:00:00 UTC 2019
SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
Developmental cell
Zhang J,Chen M,Zhu Y,Dai X,Dang F,Ren J,Ren S,Shulga YV,Beca F,Gan W,Wu F,Lin YM,Zhou X,DeCaprio JA,Beck AH,Lu KP,Huang J,Zhao C,Sun Y,Gao X,Pandolfi PP,Wei W
Mon Feb 11 00:00:00 UTC 2019
SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
Developmental cell
Zhang J,Chen M,Zhu Y,Dai X,Dang F,Ren J,Ren S,Shulga YV,Beca F,Gan W,Wu F,Lin YM,Zhou X,DeCaprio JA,Beck AH,Lu KP,Huang J,Zhao C,Sun Y,Gao X,Pandolfi PP,Wei W
Mon Feb 11 00:00:00 UTC 2019
SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway.
OncoTargets and therapy
Li Y,Yu Q,Li R,Luo J,Yuan D,Song J,Sun Y,Long T,Yang Z
Mon Apr 11 00:00:00 UTC 2022
SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway.
OncoTargets and therapy
Li Y,Yu Q,Li R,Luo J,Yuan D,Song J,Sun Y,Long T,Yang Z
Mon Apr 11 00:00:00 UTC 2022
SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation.
American journal of cancer research
Dong Y,Zhang D,Cai M,Luo Z,Zhu Y,Gong L,Lei Y,Tan X,Zhu Q,Han S
Thu Oct 01 00:00:00 UTC 2020
The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.
EMBO molecular medicine
Yan Y,Ma J,Wang D,Lin D,Pang X,Wang S,Zhao Y,Shi L,Xue H,Pan Y,Zhang J,Wahlestedt C,Giles FJ,Chen Y,Gleave ME,Collins CC,Ye D,Wang Y,Huang H
Thu Nov 07 00:00:00 UTC 2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.
Nature communications
Bufalieri F,Infante P,Bernardi F,Caimano M,Romania P,Moretti M,Lospinoso Severini L,Talbot J,Melaiu O,Tanori M,Di Magno L,Bellavia D,Capalbo C,Puget S,De Smaele E,Canettieri G,Guardavaccaro D,Busino L,Peschiaroli A,Pazzaglia S,Giannini G,Melino G,Locatelli F,Gulino A,Ayrault O,Fruci D,Di Marcotullio L
Wed Jul 24 00:00:00 UTC 2019
SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.
Experimental cell research
Tan P,Wang A,Chen H,Du Y,Qian B,Shi H,Zhang Y,Xia X,Fu W
Fri Nov 01 00:00:00 UTC 2019
SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.
Experimental cell research
Tan P,Wang A,Chen H,Du Y,Qian B,Shi H,Zhang Y,Xia X,Fu W
Fri Nov 01 00:00:00 UTC 2019
SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG.
Cell death & disease
Tan P,Xu Y,Du Y,Wu L,Guo B,Huang S,Zhu J,Li B,Lin F,Yao L
Thu Oct 17 00:00:00 UTC 2019
Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha.
Life sciences
Xiao X,Shen Y,Yin L,He J,Ni X,Luo G,Chen X,Zhu W,Zhong J,Liu J,Peng X,Zu X
Sun Dec 15 00:00:00 UTC 2019
The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation.
Genes & development
Sun S,Kelekar S,Kliewer SA,Mangelsdorf DJ
Thu Aug 01 00:00:00 UTC 2019
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Nature
Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W
Thu Jan 04 00:00:00 UTC 2018
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Nature
Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W
Thu Jan 04 00:00:00 UTC 2018
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Nature
Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W
Thu Jan 04 00:00:00 UTC 2018
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Nature
Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W
Thu Jan 04 00:00:00 UTC 2018
DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.
Molecular cell
Jin X,Yan Y,Wang D,Ding D,Ma T,Ye Z,Jimenez R,Wang L,Wu H,Huang H
Thu Aug 16 00:00:00 UTC 2018
DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.
Molecular cell
Jin X,Yan Y,Wang D,Ding D,Ma T,Ye Z,Jimenez R,Wang L,Wu H,Huang H
Thu Aug 16 00:00:00 UTC 2018
SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Nucleic acids research
Hjorth-Jensen K,Maya-Mendoza A,Dalgaard N,Sigurðsson JO,Bartek J,Iglesias-Gato D,Olsen JV,Flores-Morales A
Fri Oct 12 00:00:00 UTC 2018
SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Nucleic acids research
Hjorth-Jensen K,Maya-Mendoza A,Dalgaard N,Sigurðsson JO,Bartek J,Iglesias-Gato D,Olsen JV,Flores-Morales A
Fri Oct 12 00:00:00 UTC 2018
SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Nucleic acids research
Hjorth-Jensen K,Maya-Mendoza A,Dalgaard N,Sigurðsson JO,Bartek J,Iglesias-Gato D,Olsen JV,Flores-Morales A
Fri Oct 12 00:00:00 UTC 2018
SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Nucleic acids research
Hjorth-Jensen K,Maya-Mendoza A,Dalgaard N,Sigurðsson JO,Bartek J,Iglesias-Gato D,Olsen JV,Flores-Morales A
Fri Oct 12 00:00:00 UTC 2018
Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.
EMBO molecular medicine
Yan Y,An J,Yang Y,Wu D,Bai Y,Cao W,Ma L,Chen J,Yu Z,He Y,Jin X,Pan Y,Ma T,Wang S,Hou X,Weroha SJ,Karnes RJ,Zhang J,Westendorf JJ,Wang L,Chen Y,Xu W,Zhu R,Wang D,Huang H
Sun Apr 01 00:00:00 UTC 2018
Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.
EMBO molecular medicine
Yan Y,An J,Yang Y,Wu D,Bai Y,Cao W,Ma L,Chen J,Yu Z,He Y,Jin X,Pan Y,Ma T,Wang S,Hou X,Weroha SJ,Karnes RJ,Zhang J,Westendorf JJ,Wang L,Chen Y,Xu W,Zhu R,Wang D,Huang H
Sun Apr 01 00:00:00 UTC 2018
The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.
Cancer research
Ding M,Lu X,Wang C,Zhao Q,Ge J,Xia Q,Wang J,Zen K,Zhang CY,Zhang C
Sat Dec 15 00:00:00 UTC 2018
The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.
Cancer research
Ding M,Lu X,Wang C,Zhao Q,Ge J,Xia Q,Wang J,Zen K,Zhang CY,Zhang C
Sat Dec 15 00:00:00 UTC 2018
The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.
Cancer research
Ding M,Lu X,Wang C,Zhao Q,Ge J,Xia Q,Wang J,Zen K,Zhang CY,Zhang C
Sat Dec 15 00:00:00 UTC 2018
The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.
Cancer research
Ding M,Lu X,Wang C,Zhao Q,Ge J,Xia Q,Wang J,Zen K,Zhang CY,Zhang C
Sat Dec 15 00:00:00 UTC 2018
miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways.
Molecular oncology
Wang LQ,Yu P,Li B,Guo YH,Liang ZR,Zheng LL,Yang JH,Xu H,Liu S,Zheng LS,Zhou H,Qu LH
Thu Nov 01 00:00:00 UTC 2018
miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways.
Molecular oncology
Wang LQ,Yu P,Li B,Guo YH,Liang ZR,Zheng LL,Yang JH,Xu H,Liu S,Zheng LS,Zhou H,Qu LH
Thu Nov 01 00:00:00 UTC 2018
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
Biochemical and biophysical research communications
Ji P,Liang S,Li P,Xie C,Li J,Zhang K,Zheng X,Feng M,Li Q,Jiao H,Chi X,Zhao W,Zhang S,Wang X
Sat Jul 07 00:00:00 UTC 2018
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
Biochemical and biophysical research communications
Ji P,Liang S,Li P,Xie C,Li J,Zhang K,Zheng X,Feng M,Li Q,Jiao H,Chi X,Zhao W,Zhang S,Wang X
Sat Jul 07 00:00:00 UTC 2018
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
Biochemical and biophysical research communications
Ji P,Liang S,Li P,Xie C,Li J,Zhang K,Zheng X,Feng M,Li Q,Jiao H,Chi X,Zhao W,Zhang S,Wang X
Sat Jul 07 00:00:00 UTC 2018
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
Biochemical and biophysical research communications
Ji P,Liang S,Li P,Xie C,Li J,Zhang K,Zheng X,Feng M,Li Q,Jiao H,Chi X,Zhao W,Zhang S,Wang X
Sat Jul 07 00:00:00 UTC 2018
SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Nucleic acids research
Hjorth-Jensen K,Maya-Mendoza A,Dalgaard N,Sigurðsson JO,Bartek J,Iglesias-Gato D,Olsen JV,Flores-Morales A
Fri Oct 12 00:00:00 UTC 2018
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Journal of experimental & clinical cancer research : CR
Ma J,Chang K,Peng J,Shi Q,Gan H,Gao K,Feng K,Xu F,Zhang H,Dai B,Zhu Y,Shi G,Shen Y,Zhu Y,Qin X,Li Y,Zhang P,Ye D,Wang C
Wed Jul 11 00:00:00 UTC 2018
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Journal of experimental & clinical cancer research : CR
Ma J,Chang K,Peng J,Shi Q,Gan H,Gao K,Feng K,Xu F,Zhang H,Dai B,Zhu Y,Shi G,Shen Y,Zhu Y,Qin X,Li Y,Zhang P,Ye D,Wang C
Wed Jul 11 00:00:00 UTC 2018
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.
Nature medicine
Zhang P,Wang D,Zhao Y,Ren S,Gao K,Ye Z,Wang S,Pan CW,Zhu Y,Yan Y,Yang Y,Wu D,He Y,Zhang J,Lu D,Liu X,Yu L,Zhao S,Li Y,Lin D,Wang Y,Wang L,Chen Y,Sun Y,Wang C,Huang H
Fri Sep 01 00:00:00 UTC 2017
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.
Nature medicine
Zhang P,Wang D,Zhao Y,Ren S,Gao K,Ye Z,Wang S,Pan CW,Zhu Y,Yan Y,Yang Y,Wu D,He Y,Zhang J,Lu D,Liu X,Yu L,Zhao S,Li Y,Lin D,Wang Y,Wang L,Chen Y,Sun Y,Wang C,Huang H
Fri Sep 01 00:00:00 UTC 2017
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
Nature medicine
Dai X,Gan W,Li X,Wang S,Zhang W,Huang L,Liu S,Zhong Q,Guo J,Zhang J,Chen T,Shimizu K,Beca F,Blattner M,Vasudevan D,Buckley DL,Qi J,Buser L,Liu P,Inuzuka H,Beck AH,Wang L,Wild PJ,Garraway LA,Rubin MA,Barbieri CE,Wong KK,Muthuswamy SK,Huang J,Chen Y,Bradner JE,Wei W
Fri Sep 01 00:00:00 UTC 2017
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
Nature medicine
Dai X,Gan W,Li X,Wang S,Zhang W,Huang L,Liu S,Zhong Q,Guo J,Zhang J,Chen T,Shimizu K,Beca F,Blattner M,Vasudevan D,Buckley DL,Qi J,Buser L,Liu P,Inuzuka H,Beck AH,Wang L,Wild PJ,Garraway LA,Rubin MA,Barbieri CE,Wong KK,Muthuswamy SK,Huang J,Chen Y,Bradner JE,Wei W
Fri Sep 01 00:00:00 UTC 2017
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Cancer letters
Zhang L,Peng S,Dai X,Gan W,Nie X,Wei W,Hu G,Guo J
Sat Apr 01 00:00:00 UTC 2017
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Cancer letters
Zhang L,Peng S,Dai X,Gan W,Nie X,Wei W,Hu G,Guo J
Sat Apr 01 00:00:00 UTC 2017
Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.
Cancer letters
Wu F,Dai X,Gan W,Wan L,Li M,Mitsiades N,Wei W,Ding Q,Zhang J
Sat Jan 28 00:00:00 UTC 2017
Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.
Cancer letters
Wu F,Dai X,Gan W,Wan L,Li M,Mitsiades N,Wei W,Ding Q,Zhang J
Sat Jan 28 00:00:00 UTC 2017
Identification of SPOP related metabolic pathways in prostate cancer.
Oncotarget
Yan M,Qi H,Li J,Ye G,Shao Y,Li T,Liu J,Piao HL,Xu G
Tue Nov 28 00:00:00 UTC 2017
Identification of SPOP related metabolic pathways in prostate cancer.
Oncotarget
Yan M,Qi H,Li J,Ye G,Shao Y,Li T,Liu J,Piao HL,Xu G
Tue Nov 28 00:00:00 UTC 2017
Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.
Oncotarget
Tan Y,Ci Y,Dai X,Wu F,Guo J,Liu D,North BJ,Huo J,Zhang J
Tue Jul 18 00:00:00 UTC 2017
Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.
Oncotarget
Tan Y,Ci Y,Dai X,Wu F,Guo J,Liu D,North BJ,Huo J,Zhang J
Tue Jul 18 00:00:00 UTC 2017
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
PLoS genetics
Jin X,Wang J,Gao K,Zhang P,Yao L,Tang Y,Tang L,Ma J,Xiao J,Zhang E,Zhu J,Zhang B,Zhao SM,Li Y,Ren S,Huang H,Yu L,Wang C
Sat Apr 01 00:00:00 UTC 2017
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
PLoS genetics
Jin X,Wang J,Gao K,Zhang P,Yao L,Tang Y,Tang L,Ma J,Xiao J,Zhang E,Zhu J,Zhang B,Zhao SM,Li Y,Ren S,Huang H,Yu L,Wang C
Sat Apr 01 00:00:00 UTC 2017
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
Molecular cell
Gan W,Dai X,Lunardi A,Li Z,Inuzuka H,Liu P,Varmeh S,Zhang J,Cheng L,Sun Y,Asara JM,Beck AH,Huang J,Pandolfi PP,Wei W
Thu Sep 17 00:00:00 UTC 2015
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
Molecular cell
Gan W,Dai X,Lunardi A,Li Z,Inuzuka H,Liu P,Varmeh S,Zhang J,Cheng L,Sun Y,Asara JM,Beck AH,Huang J,Pandolfi PP,Wei W
Thu Sep 17 00:00:00 UTC 2015
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Molecular cell
An J,Ren S,Murphy SJ,Dalangood S,Chang C,Pang X,Cui Y,Wang L,Pan Y,Zhang X,Zhu Y,Wang C,Halling GC,Cheng L,Sukov WR,Karnes RJ,Vasmatzis G,Zhang Q,Zhang J,Cheville JC,Yan J,Sun Y,Huang H
Thu Sep 17 00:00:00 UTC 2015
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Molecular cell
An J,Ren S,Murphy SJ,Dalangood S,Chang C,Pang X,Cui Y,Wang L,Pan Y,Zhang X,Zhu Y,Wang C,Halling GC,Cheng L,Sukov WR,Karnes RJ,Vasmatzis G,Zhang Q,Zhang J,Cheville JC,Yan J,Sun Y,Huang H
Thu Sep 17 00:00:00 UTC 2015
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Molecular cell
An J,Ren S,Murphy SJ,Dalangood S,Chang C,Pang X,Cui Y,Wang L,Pan Y,Zhang X,Zhu Y,Wang C,Halling GC,Cheng L,Sukov WR,Karnes RJ,Vasmatzis G,Zhang Q,Zhang J,Cheville JC,Yan J,Sun Y,Huang H
Thu Sep 17 00:00:00 UTC 2015
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Molecular cell
An J,Ren S,Murphy SJ,Dalangood S,Chang C,Pang X,Cui Y,Wang L,Pan Y,Zhang X,Zhu Y,Wang C,Halling GC,Cheng L,Sukov WR,Karnes RJ,Vasmatzis G,Zhang Q,Zhang J,Cheville JC,Yan J,Sun Y,Huang H
Thu Sep 17 00:00:00 UTC 2015
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.
American journal of cancer research
Gao K,Jin X,Tang Y,Ma J,Peng J,Yu L,Zhang P,Wang C
Tue Dec 22 00:00:00 UTC 2015
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.
American journal of cancer research
Gao K,Jin X,Tang Y,Ma J,Peng J,Yu L,Zhang P,Wang C
Tue Dec 22 00:00:00 UTC 2015
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.
American journal of cancer research
Gao K,Jin X,Tang Y,Ma J,Peng J,Yu L,Zhang P,Wang C
Tue Dec 22 00:00:00 UTC 2015
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.
American journal of cancer research
Gao K,Jin X,Tang Y,Ma J,Peng J,Yu L,Zhang P,Wang C
Tue Dec 22 00:00:00 UTC 2015
SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.
Journal of experimental & clinical cancer research : CR
Zeng C,Wang Y,Lu Q,Chen J,Zhang J,Liu T,Lv N,Luo S
Thu Sep 11 00:00:00 UTC 2014
SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.
Journal of experimental & clinical cancer research : CR
Zeng C,Wang Y,Lu Q,Chen J,Zhang J,Liu T,Lv N,Luo S
Thu Sep 11 00:00:00 UTC 2014
SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.
Journal of experimental & clinical cancer research : CR
Zeng C,Wang Y,Lu Q,Chen J,Zhang J,Liu T,Lv N,Luo S
Thu Sep 11 00:00:00 UTC 2014
SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.
Journal of experimental & clinical cancer research : CR
Zeng C,Wang Y,Lu Q,Chen J,Zhang J,Liu T,Lv N,Luo S
Thu Sep 11 00:00:00 UTC 2014
