Product References
AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.
Developmental cell
Wang X,Jin J,Wan F,Zhao L,Chu H,Chen C,Liao G,Liu J,Yu Y,Teng H,Fang L,Jiang C,Pan W,Xie X,Li J,Lu X,Jiang X,Ge X,Ye D,Wang P
Mon Feb 11 00:00:00 EST 2019
SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
Developmental cell
Zhang J,Chen M,Zhu Y,Dai X,Dang F,Ren J,Ren S,Shulga YV,Beca F,Gan W,Wu F,Lin YM,Zhou X,DeCaprio JA,Beck AH,Lu KP,Huang J,Zhao C,Sun Y,Gao X,Pandolfi PP,Wei W
Mon Feb 11 00:00:00 EST 2019
The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.
Cancer research
Ding M,Lu X,Wang C,Zhao Q,Ge J,Xia Q,Wang J,Zen K,Zhang CY,Zhang C
Sat Dec 15 00:00:00 EST 2018
The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.
Cancer research
Ding M,Lu X,Wang C,Zhao Q,Ge J,Xia Q,Wang J,Zen K,Zhang CY,Zhang C
Sat Dec 15 00:00:00 EST 2018
miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways.
Molecular oncology
Wang LQ,Yu P,Li B,Guo YH,Liang ZR,Zheng LL,Yang JH,Xu H,Liu S,Zheng LS,Zhou H,Qu LH
Thu Nov 01 00:00:00 EDT 2018
SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Nucleic acids research
Hjorth-Jensen K,Maya-Mendoza A,Dalgaard N,Sigurðsson JO,Bartek J,Iglesias-Gato D,Olsen JV,Flores-Morales A
Fri Oct 12 00:00:00 EDT 2018
SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Nucleic acids research
Hjorth-Jensen K,Maya-Mendoza A,Dalgaard N,Sigurðsson JO,Bartek J,Iglesias-Gato D,Olsen JV,Flores-Morales A
Fri Oct 12 00:00:00 EDT 2018
DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.
Molecular cell
Jin X,Yan Y,Wang D,Ding D,Ma T,Ye Z,Jimenez R,Wang L,Wu H,Huang H
Thu Aug 16 00:00:00 EDT 2018
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Journal of experimental & clinical cancer research : CR
Ma J,Chang K,Peng J,Shi Q,Gan H,Gao K,Feng K,Xu F,Zhang H,Dai B,Zhu Y,Shi G,Shen Y,Zhu Y,Qin X,Li Y,Zhang P,Ye D,Wang C
Wed Jul 11 00:00:00 EDT 2018
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
Biochemical and biophysical research communications
Ji P,Liang S,Li P,Xie C,Li J,Zhang K,Zheng X,Feng M,Li Q,Jiao H,Chi X,Zhao W,Zhang S,Wang X
Sat Jul 07 00:00:00 EDT 2018
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
Biochemical and biophysical research communications
Ji P,Liang S,Li P,Xie C,Li J,Zhang K,Zheng X,Feng M,Li Q,Jiao H,Chi X,Zhao W,Zhang S,Wang X
Sat Jul 07 00:00:00 EDT 2018
Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.
EMBO molecular medicine
Yan Y,An J,Yang Y,Wu D,Bai Y,Cao W,Ma L,Chen J,Yu Z,He Y,Jin X,Pan Y,Ma T,Wang S,Hou X,Weroha SJ,Karnes RJ,Zhang J,Westendorf JJ,Wang L,Chen Y,Xu W,Zhu R,Wang D,Huang H
Sun Apr 01 00:00:00 EDT 2018
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Nature
Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W
Thu Jan 04 00:00:00 EST 2018
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Nature
Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W
Thu Jan 04 00:00:00 EST 2018
Identification of SPOP related metabolic pathways in prostate cancer.
Oncotarget
Yan M,Qi H,Li J,Ye G,Shao Y,Li T,Liu J,Piao HL,Xu G
Tue Nov 28 00:00:00 EST 2017
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
Nature medicine
Dai X,Gan W,Li X,Wang S,Zhang W,Huang L,Liu S,Zhong Q,Guo J,Zhang J,Chen T,Shimizu K,Beca F,Blattner M,Vasudevan D,Buckley DL,Qi J,Buser L,Liu P,Inuzuka H,Beck AH,Wang L,Wild PJ,Garraway LA,Rubin MA,Barbieri CE,Wong KK,Muthuswamy SK,Huang J,Chen Y,Bradner JE,Wei W
Fri Sep 01 00:00:00 EDT 2017
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.
Nature medicine
Zhang P,Wang D,Zhao Y,Ren S,Gao K,Ye Z,Wang S,Pan CW,Zhu Y,Yan Y,Yang Y,Wu D,He Y,Zhang J,Lu D,Liu X,Yu L,Zhao S,Li Y,Lin D,Wang Y,Wang L,Chen Y,Sun Y,Wang C,Huang H
Fri Sep 01 00:00:00 EDT 2017
Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.
Oncotarget
Tan Y,Ci Y,Dai X,Wu F,Guo J,Liu D,North BJ,Huo J,Zhang J
Tue Jul 18 00:00:00 EDT 2017
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
PLoS genetics
Jin X,Wang J,Gao K,Zhang P,Yao L,Tang Y,Tang L,Ma J,Xiao J,Zhang E,Zhu J,Zhang B,Zhao SM,Li Y,Ren S,Huang H,Yu L,Wang C
Sat Apr 01 00:00:00 EDT 2017
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Cancer letters
Zhang L,Peng S,Dai X,Gan W,Nie X,Wei W,Hu G,Guo J
Sat Apr 01 00:00:00 EDT 2017
Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.
Cancer letters
Wu F,Dai X,Gan W,Wan L,Li M,Mitsiades N,Wei W,Ding Q,Zhang J
Sat Jan 28 00:00:00 EST 2017
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.
American journal of cancer research
Gao K,Jin X,Tang Y,Ma J,Peng J,Yu L,Zhang P,Wang C
Tue Dec 22 00:00:00 EST 2015
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.
American journal of cancer research
Gao K,Jin X,Tang Y,Ma J,Peng J,Yu L,Zhang P,Wang C
Tue Dec 22 00:00:00 EST 2015
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
Molecular cell
Gan W,Dai X,Lunardi A,Li Z,Inuzuka H,Liu P,Varmeh S,Zhang J,Cheng L,Sun Y,Asara JM,Beck AH,Huang J,Pandolfi PP,Wei W
Thu Sep 17 00:00:00 EDT 2015
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Molecular cell
An J,Ren S,Murphy SJ,Dalangood S,Chang C,Pang X,Cui Y,Wang L,Pan Y,Zhang X,Zhu Y,Wang C,Halling GC,Cheng L,Sukov WR,Karnes RJ,Vasmatzis G,Zhang Q,Zhang J,Cheville JC,Yan J,Sun Y,Huang H
Thu Sep 17 00:00:00 EDT 2015
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Molecular cell
An J,Ren S,Murphy SJ,Dalangood S,Chang C,Pang X,Cui Y,Wang L,Pan Y,Zhang X,Zhu Y,Wang C,Halling GC,Cheng L,Sukov WR,Karnes RJ,Vasmatzis G,Zhang Q,Zhang J,Cheville JC,Yan J,Sun Y,Huang H
Thu Sep 17 00:00:00 EDT 2015