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Proteintech
SPOP Polyclonal Antibody
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Product Details
16750-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPOP Fusion Protein Ag10215 (1-374 aa encoded by BC003385)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSRVPSPPP PAEMSSGPVA ESWCYTQIKV VKFSYMWTIN NFSFCREEMG EVIKSSTFSS GANDKLKWCL RVNPKGLDEE SKDYLSLYLL LVSCPKSEVR AKFKFSILNA KGEETKAMES QRAYRFVQGK DWGFKKFIRR DFLLDEANGL LPDDKLTLFC EVSVVQDSVN ISGQNTMNMV KVPECRLADE LGGLWENSRF TDCCLCVAGQ EFQAHKAILA ARSPVFSAMF EHEMEESKKN RVEINDVEPE VFKEMMCFIY TGKAPNLDKM ADDLLAAADK YALERLKVMC EDALCSNLSV ENAAEILILA DLHSADQLKT QAVDFINYHA SDVLETSGWK SMVVSHPHLV AEAYRSLASA QCPFLGPPRK RLKQS (1-374 aa encoded by BC003385)
Target Information
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HIB homolog 1; PDX-1 C-terminal-interacting factor 1; Roadkill homolog 1; speckle type POZ protein; Speckle-type POZ protein
Gene Aliases: AI315626; BTBD32; Pcif1; SPOP; TEF2
UniProt ID: (Human) O43791, (Mouse) Q6ZWS8
Entrez Gene ID: (Human) 8405, (Mouse) 20747, (Rat) 287643
regulation of proteolysis
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription from RNA polymerase II promoter
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of type B pancreatic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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