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Invitrogen
SPRED1 Polyclonal Antibody
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Product Details
PA5-20617
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Hamster,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 20 amino acid peptide near the center of the human Spred1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is mouse brain tissue lysate.
PA5-20617 can be used with blocking peptide PEP-0737.
Target Information
The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: protein phosphatase 1, regulatory subunit 147; Spred-1; sprouty protein with EVH-1 domain 1, related sequence; sprouty related, EVH1 domain containing 1; sprouty-related protein 1 with EVH-1 domain; sprouty-related, EVH1 domain containing 1; Sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
Gene Aliases: 5730461F13Rik; AL024345; AW047647; hSpred1; NFLS; PPP1R147; spred-1; SPRED1
UniProt ID: (Human) Q7Z699, (Mouse) Q924S8
Entrez Gene ID: (Human) 161742, (Rat) 296072, (Mouse) 114715
MAPK cascade
inactivation of MAPK activity
multicellular organism development
fibroblast growth factor receptor signaling pathway
negative regulation of peptidyl-threonine phosphorylation
negative regulation of phosphatase activity
positive regulation of DNA damage response, signal transduction by p53 class mediator
regulation of protein deacetylation
negative regulation of protein serine/threonine kinase activity
regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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