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Invitrogen
SPRY1 Polyclonal Antibody
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Product Details
PA5-149136
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human SPRY1, Met1-Lys178
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1-4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing pathways leading to MAP kinase activation. Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts. A recent study shows that Sprouty-1 and -2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; Protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling; sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); Spry-1; Spry1
Gene Aliases: hSPRY1; SPRY1
UniProt ID: (Human) O43609
Entrez Gene ID: (Human) 10252
establishment of mitotic spindle orientation
metanephros development
ureteric bud development
organ induction
negative regulation of cell proliferation
regulation of signal transduction
negative regulation of epithelial to mesenchymal transition
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of Ras protein signal transduction
animal organ development
negative regulation of neurotrophin TRK receptor signaling pathway
bud elongation involved in lung branching
epithelial to mesenchymal transition involved in cardiac fibroblast development
ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
negative regulation of lens fiber cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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