FIGURE: 1 / 6
Immunogen sequence: MEARAQSGN GSQPLLQTPR DGGRQRGEPD PRDALTQQVH VLSLDQIRAI RNTNEYTEGP TVVPRPGLKP APRPSTQHKH ERLHGLPEHR QPPRLQHSQV HSSARAPLSR SISTVSSGSR SSTRTSTSSS SSEQRLLGSS FSSGPVADGI IRVQPKSELK PGELKPLSKE DLGLHAYRCE DCGKCKCKEC TYPRPLPSDW ICDKQCLCSA QNVIDYGTCV CCVKGLFYHC SNDDEDNCAD NPCSCSQSHC CTRWSAMGVM SLFLPCLWCY LPAKGCLKLC QGCYDRVNRP GCRCKNSNTV CCKVPTVPPR NFEKPT (1-315 aa encoded by B C015745)
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
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Protein Aliases: MGC23039; Protein sprouty homolog 2; sprouty 2; Spry-2
Gene Aliases: hSPRY2; IGAN3; sprouty2; SPRY2
Molecular Function: scaffold/adaptor protein