The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.
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Protein Aliases: HSAN; HSAN1; HSN1; LBC1; LCB 1; LCB1; Long chain base biosynthesis protein 1; serine C-palmitoyltransferase; Serine palmitoyltransferase 1; serine palmitoyltransferase subunit 1; serine palmitoyltransferase, long chain base subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1; SPTI; SPTLC1
Gene Aliases: AW552086; C77762; E030036H05; HSAN1; HSN1; LBC1; LCB1; rCG_44191; RGD1306617; SPT1; SPTI; SPTLC1