A suggested positive control is human lung tissue lysate.
PA5-21141 can be used with blocking peptide PEP-1255.
Serine palmitoyltransferase (SPT) is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine.
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Protein Aliases: hLCB1; HSAN; LCB 1; Long chain base biosynthesis protein 1; MGC14645; RP11-118F2.1; serine C-palmitoyltransferase; Serine palmitoyltransferase 1; serine palmitoyltransferase, long chain base subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1
Gene Aliases: HSAN1; HSN1; LBC1; LCB1; SPT1; SPTI; SPTLC1
UniProt ID: (Human) O15269
Entrez Gene ID: (Human) 10558
Molecular Function: transaminase