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Invitrogen
SPTY2D1 Polyclonal Antibody
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Product Details
PA5-65486
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human SPTY2D1. Recombinant protein control fragment (Product #RP-104840).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SGPGRSISGSI PAGRTVSNSV PGRPVSSLGP GQTVSSSGPT IKPKCTVVSE TISSKNIISR SSNGQMNGMK PPLSGYRAAQ GPQRLPFPTG YKRQREYEE
Highest antigen sequence identity to the following orthologs - mouse 86%, rat 83%.
Target Information
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription. Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686I068; FLJ39441; Protein KU002155; Protein SPT2 homolog; SPT2 domain-containing protein 1; SPT2, Suppressor of Ty, domain containing 1
Gene Aliases: Spt2; SPTY2D1
UniProt ID: (Human) Q68D10
Entrez Gene ID: (Human) 144108
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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