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Positive Samples: SKOV3, Mouse liver, Mouse kidney, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein
Immunogen sequence: VSVSSHFVGF LMKNAPQFKA NHAELILANP SPVLIYQISS SETRVLVDIR GEMPRNLREY MVEKIYPQIP DHLKEPFLEA TDNSHLRSMP ASFLPPSSVK K
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.
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Protein Aliases: FLJ30795; SE; Squalene epoxidase; Squalene monooxygenase
Gene Aliases: AI323792; ERG1; SQLE
UniProt ID: (Human) Q14534, (Mouse) P52019, (Rat) P52020
Entrez Gene ID: (Human) 6713, (Mouse) 20775, (Rat) 29230
Molecular Function: oxidoreductase oxygenase metabolite interconversion enzyme
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