This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
PA5-27247 targets SQSTM1 in IF and WB applications and shows reactivity with Human samples.
The PA5-27247 immunogen is synthetic peptide corresponding to a region within amino acids 157 and 251 of Human SQSTM1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
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Protein Aliases: A170; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; OSIL; oxidative stress induced; oxidative stress induced like; p62B; PDB3; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Sequestosome-1; STONE14; ubiquitin-bi; Ubiquitin-binding protein p62; ZIP3
Gene Aliases: A170; FTDALS3; ORCA; OSF-6; Osi; OSIL; p60; p62; p62B; PDB3; sb:cb621; SQSTM1; STAP; STONE14; zgc:85784; ZIP3