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Invitrogen
SRC Polyclonal Antibody
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FIGURE: 1 / 1
SRC Antibody (PA5-117534) in WB
Western Blot analysis of SRC using SRC Polyclonal Antibody (Product # PA5-117534) at 2 µg/mL. Positive WB detected in: Zebrafish tissue. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 61 kDa. Observed band size: 61 kDa
Product Details
PA5-117534
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Zebrafish Proto-oncogene tyrosine-protein kinase Src protein (2-146aa)
Conjugate
Form
Liquid
Concentration
2.464 mg/mL
Amount
246.4 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRC is involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.10.2; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; pp60c-src; pp60src; protein-tyrosine kinase; Proto-oncogene c-Src; Proto-oncogene tyrosine-protein kinase Src; RP5-823N20.1; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Gene Aliases: c-src; fc54g04; p60-Src; sb:cb864; src; wu:fc54g04
UniProt ID: (Zebrafish) Q1JPZ3
Entrez Gene ID: (Zebrafish) 325084
response to yeast
protein phosphorylation
cell cycle
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
phosphorylation
cell differentiation
osteoclast development
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
regulation of vascular permeability
innate immune response
bone resorption
posterior lateral line neuromast primordium migration
progesterone receptor signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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