This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-29482 targets NCOA2 in IF and WB applications and shows reactivity with Human samples.
The PA5-29482 immunogen is recombinant fragment corresponding to a region within amino acids 1048 and 1321 of Human NCOA2.
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The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene and apos;s transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).
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Protein Aliases: bHLHe75; Class E basic helix-loop-helix protein 75; glucocorticoid receptor-interacting protein-1; GRIP1; hTIF2; KAT13C; NCoA-2; Nuclear receptor coactivator 2; p160 steroid receptor coactivator 2; SRC2; TIF2; Transcriptional intermediary factor 2
Gene Aliases: BHLHE75; GRIP1; KAT13C; NCoA-2; NCOA2; SRC2; TIF2
UniProt ID: (Human) Q15596
Entrez Gene ID: (Human) 10499