PA1-845 detects amplified in breast cancer 1 (AIB1) from human tissues and cells.
PA1-845 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~155 kDa protein representing AIB1 from T47D cell lysate.
The PA1-845 immunogen is a synthetic peptide corresponding to residues G(3) L G E N L D P L A S D S(15) C of human AIB1.
PA1-845 can be used with blocking peptide PEP-049.
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Amplified in breast cancer-1 (AIB-1), is a member of a growing family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC-1) and glucocorticoid receptor interacting protein-1 (GRIP1).
AIB1/RAC3 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, progesterone, and peroxisome proliferator activated receptors. AIB1/RAC3 also interacts with the transcriptional integrators CREB binding protein (CBP) and p300.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACTR; AIB-1; Amplified in breast cancer 1 protein; Amplified In Breast Cancer-1; bHLHe42; CBP-interacting protein; Class E basic helix-loop-helix protein 42; NCoA-3; Nuclear receptor coactivator 3; pCIP; RAC-3; RAC3; Receptor-Associated Coactivator 3; SRC-3; SRC3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TRAM-1
Gene Aliases: ACTR; AIB-1; AIB1; BHLHE42; CAGH16; CTG26; KAT13B; NCOA3; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; TRAM1
UniProt ID: (Human) Q9Y6Q9
Entrez Gene ID: (Human) 8202