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Invitrogen
SRC3 Polyclonal Antibody
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FIGURE: 1 / 1
SRC3 Antibody (PA5149661) in ChIP
ChIP Assay of SRC3 in K562 cells. ChIP-Exo-Seq composite graph for SRC3 polyclonal antibody (Product # PA5149661). Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site.
Product Details
PA5149661
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NCOA3
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PSKVSNQDSK SPLGFYCDQN PVESSMCQSN SRDHLSDKES KESSVEGAEN QRGPLESKGH KKLLQLLTCS SDDRGHSSLT NSPLDSSCKE SSVSVTSPSG VSSSTSGGVS STSNMHGSLL QEKHRILHKL L
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.
Target Information
AIB1-AC3 recognizes AIB1, a member of the SRC-1 family of nuclear receptor coactivators with an apparent molecular weight of 160kDa. The AIB1 gene has been mapped to region 20q12 and has been shown to be amplified in breast tumors and pancreatic cancer cell lines. AIB1 interacts in a ligand-dependent fashion with the estrogen receptor to enhance estrogen-dependent transcriptional gene activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACTR; AIB-1; Amplified in breast cancer 1 protein; bHLHe42; CBP-interacting protein; Class E basic helix-loop-helix protein 42; MGC141848; NCoA-3; nuclear hormone receptor coactivator protein; nuclear receptor co-activator; Nuclear receptor coactivator 3; OTTHUMP00000031716; pCIP; RAC-3; Receptor-associated coactivator 3; RP5-1049G16.3; SRC-3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TRAM-1; unnamed protein product
Gene Aliases: ACTR; AIB-1; AIB1; BHLHE42; CAGH16; CTG26; KAT13B; NCOA3; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; TRAM1
UniProt ID: (Human) Q9Y6Q9
Entrez Gene ID: (Human) 8202
RNA polymerase II core binding
transcription cofactor activity
transcription coactivator activity
histone acetyltransferase activity
protein binding
transferase activity
transferase activity, transferring acyl groups
ligand-dependent nuclear receptor binding
thyroid hormone receptor binding
protein dimerization activity
peptide-lysine-N-acetyltransferase activity
disordered domain specific binding
chromatin remodeling
regulation of transcription, DNA-templated
cellular response to hormone stimulus
cell dedifferentiation
positive regulation of keratinocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
vitamin D receptor signaling pathway
cellular response to estradiol stimulus
nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
positive regulation of stem cell population maintenance
regulation of stem cell division
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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