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Product Details
PA5-115961
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunohistochemistry (PFA fixed) (IHC (PFA)) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human SRD5A2, corresponding to a region within N-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2900595 |
Target Information
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; MGC138457; S5AR 2; SR type 2; Steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); Type II 5-alpha reductase
Gene Aliases: SRD5A2
UniProt ID: (Human) P31213
Entrez Gene ID: (Human) 6716
Molecular Function:
dehydrogenase
steroid biosynthetic process
androgen biosynthetic process
steroid catabolic process
cell-cell signaling
androgen metabolic process
male gonad development
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phthalate metabolic process
hippocampus development
hypothalamus development
cell differentiation
male genitalia development
female genitalia development
response to nutrient levels
response to follicle-stimulating hormone
response to testosterone
response to drug
response to peptide hormone
response to steroid hormone
oxidation-reduction process
bone development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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