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SREBP-1/2 Polyclonal Antibody

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Product Details

BS-1402R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human SREBP-1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADD1; adipocyte determination and differentiation-dependent factor 1; Adipocyte determination- and differentiation-dependent factor 1; bHLHd1; bHLHd2; Class D basic helix-loop-helix protein 1; Class D basic helix-loop-helix protein 2; SREBF2; srebf2 {ECO:0000312|EMBL:AAI01903.1}; SREBP-1; SREBP-2; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding transcription factor 2; sterol response element binding protein 1; unnamed protein product

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Gene Aliases: ADD-1; ADD1; AI608257; BHLHD1; BHLHD2; D630008H06; HMD; IFAP2; lop13; nuc; SREBF1; SREBF2; Srebf2_retired; SREBP-1; SREBP-1a; SREBP-1c; SREBP-2; SREBP1; SREBP1c; SREBP2; SREBP2gc

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UniProt ID: (Human) P36956, (Human) Q12772, (Rat) P56720, (Mouse) Q9WTN3, (Rat) Q3T1I5, (Mouse) Q3U1N2

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Entrez Gene ID: (Human) 6720, (Bovine) 539361, (Bovine) 507102, (Human) 6721, (Rat) 78968, (Mouse) 20787, (Rat) 300095, (Mouse) 20788

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding protein kinase binding sterol response element binding sequence-specific DNA binding macromolecular complex binding protein dimerization activity sequence-specific double-stranded DNA binding C-8 sterol isomerase activity transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding E-box binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding protein complex binding transcription regulatory region DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding protein C-terminus binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated spermatogenesis aging cholesterol metabolic process lipid biosynthetic process response to hormone response to lead ion positive regulation of cholesterol storage response to lipid response to drug positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to low-density lipoprotein particle regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter negative regulation of cholesterol efflux regulation of cholesterol homeostasis regulation of heart rate by chemical signal circadian rhythm insulin receptor signaling pathway cellular response to starvation response to glucose positive regulation of triglyceride biosynthetic process response to organic cyclic compound regulation of fatty acid metabolic process lung development positive regulation of histone deacetylation response to food response to retinoic acid response to progesterone response to insulin cellular response to insulin stimulus response to glucagon response to peptide hormone positive regulation of cholesterol biosynthetic process negative regulation of insulin secretion regulation of insulin secretion response to cAMP response to fatty acid cellular response to fatty acid regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter lipid metabolic process cholesterol biosynthetic process response to nutrient steroid metabolic process response to xenobiotic stimulus response to fructose insulin secretion intracellular receptor signaling pathway regulation of protein stability SREBP signaling pathway mRNA transcription from RNA polymerase II promoter fat cell differentiation response to ethanol negative regulation of triglyceride metabolic process regulation of mitophagy positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of protein targeting to mitochondrion regulation of mitophagy positive regulation of protein targeting to mitochondrion regulation of Notch signaling pathway cholesterol homeostasis cellular response to low-density lipoprotein particle stimulus cellular response to laminar fluid shear stress negative regulation of beta-amyloid clearance positive regulation of fatty acid biosynthetic process
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