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SREBP-1/2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
BS-1402R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SREBP-1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adipocyte determination and differentiation-dependent factor 1; adipocyte determination- and differentiation-dependent factor 1; class D basic helix-loop-helix protein 1; class D basic helix-loop-helix protein 2; SREBF2; sterol regulatory element binding factor 2; sterol regulatory element-binding transcription factor 2; sterol response element binding protein 1; unnamed protein product
Gene Aliases: ADD-1; ADD1; bHLHd1; bHLHd2; HMD; IFAP2; lop13; nuc; Srebf2_retired; SREBP-1; SREBP-1c; SREBP-2; SREBP1; SREBP2; SREBP2gc
UniProt ID: (Human) P36956, (Human) Q12772, (Rat) P56720, (Mouse) Q9WTN3, (Mouse) Q3U1N2, (Rat) Q3T1I5
Entrez Gene ID: (Human) 6720, (Bovine) 539361, (Bovine) 507102, (Human) 6721, (Rat) 78968, (Mouse) 20787, (Mouse) 20788, (Rat) 300095
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
protein kinase binding
sterol response element binding
sequence-specific DNA binding
macromolecular complex binding
protein dimerization activity
sequence-specific double-stranded DNA binding
C-8 sterol isomerase activity
transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
E-box binding
regulation of transcription from RNA polymerase II promoter
lipid metabolic process
response to nutrient
circadian rhythm
cholesterol metabolic process
lipid biosynthetic process
cellular response to starvation
response to xenobiotic stimulus
response to fructose
positive regulation of triglyceride biosynthetic process
lung development
intracellular receptor signaling pathway
regulation of protein stability
response to food
response to retinoic acid
response to progesterone
cellular response to insulin stimulus
SREBP signaling pathway
response to glucagon
response to lipid
response to peptide hormone
response to ethanol
positive regulation of cholesterol biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to cAMP
response to fatty acid
cellular response to fatty acid
negative regulation of triglyceride metabolic process
regulation of mitophagy
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
regulation of protein localization to mitochondrion
negative regulation of transcription from RNA polymerase II promoter
regulation of heart rate by chemical signal
regulation of transcription, DNA-templated
insulin receptor signaling pathway
response to glucose
regulation of fatty acid metabolic process
response to insulin
mRNA transcription from RNA polymerase II promoter
positive regulation of innate immune response
fat cell differentiation
negative regulation of insulin secretion
positive regulation of lipid biosynthetic process
regulation of insulin secretion
positive regulation of fatty acid biosynthetic process
regulation of Notch signaling pathway
positive regulation of cholesterol storage
cellular response to low-density lipoprotein particle stimulus
cellular response to laminar fluid shear stress
negative regulation of cholesterol efflux
negative regulation of beta-amyloid clearance
positive regulation of establishment of protein localization to mitochondrion
response to hormone
cholesterol homeostasis
spermatogenesis
response to lead ion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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