Immunogen sequence: LEPLKTSPVV APTSEPSSPL HTQLLKDPEP AFQRSASTAG DIACAFRPVK SVKMAAPVKP PATRPKPTVF PKTNATSPGV NSSTSPQST
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 99%.
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
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Protein Aliases: Formin-binding protein 2; Rho GTPase-activating protein 34; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase-activating protein 2; srGAP2
Gene Aliases: ARHGAP34; FNBP2; KIAA0456; SRGAP2; SRGAP2A; SRGAP3
UniProt ID: (Human) O75044
Entrez Gene ID: (Human) 23380