The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. SRM synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
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Protein Aliases: Putrescine aminopropyltransferase; SPDSY; Spermidine synthase; spermidine synthase-1
Gene Aliases: PAPT; SPDSY; SPS1; SRM; SRML1
UniProt ID: (Human) P19623
Entrez Gene ID: (Human) 6723
Molecular Function: transferase