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Immunogen sequence: QEESESPVE RPLKENPPNK MTQEKLEESS TIGQDQTLME RDTEGGAAEI NCNGVIEVIN YTQNSNNETL RHKEDLHNAN DCDVQNLNQE SSFLSSQNGD SSTSQETDSC TPITSEVSDT MVCQSSSTVG QSFSEQHISQ LQESIRAEIP CEDEQEQEHN GPLDNKGKST AGNFLVNPLE PKNAEKLKVK IADLGNACWV HKHFTEDIQT RQYRSLEVLI GSGYNTPADI WSTACMAFEL ATGDYLFEPH SGEEYTRDED HIALIIELLG KVPRKLIVAG KYSKEFFTKK GDLKHITKLK PWGLFEVLVE KYEWSQEEAA GFTDFLLPML ELIPEKRATA AECLRHPWLN S (306-655 aa encoded by BC038292)
SRPK1 is a serine/threonine kinase that plays a role in the regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. SRPK1 localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.
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Protein Aliases: OTTHUMP00000016277; Serine/arginine-rich protein-specific kinase 1; serine/arginine-rich splicing factor kinase 1; serine/threonine-protein kinase SRPK1; SFRS protein kinase 1; SR protein-specific kinase 1; SR-protein-specific kinase 1; SRPK1; SRSF protein kinase 1
Gene Aliases: AU017960; SFRSK1; SRPK1
Molecular Function: non-receptor serine/threonine protein kinase