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Abnova
SRPX Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
SRPX Antibody (H00008406-B01P) in WB
Western Blot analysis of SRPX expression in transfected 293T cell line (H00008406-T01) by SRPX MaxPab polyclonal antibody.
Lane 1: SRPX transfected lysate(51.04 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SRPX transfected lysate(51.04 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00008406-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SRPX (NP_006298.1, 1 a.a. approximately 464 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MGSPAHRPAL LLLLPPLLLL LLLRVPPSRS FPGSGDSPLE DDEVGYSHPR YKDTPWCSPI KVKYGDVYCR APQGGYYKTA LGTRCDIRCQ KGYELHGSSL LICQSNKRWS DKVICKQKRC PTLAMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIQYT VYDRAENKGT CKFRVKVRVK RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP ARVCQSNLAW SGTEPTCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG MLQQAQCGLD LRHITVVELV GVFPTLIGRI GAKIMPPALA LQLRLLLRIP LYSFSMVLVD KHGMDKERYV SLVMPVALFN LIDTFPLRKE EMVLQAEMSQ TCNT
Target Information
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 83p; Sushi repeat-containing protein SRPX; sushi-repeat containing protein, X-linked; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-linked
Gene Aliases: DRS; ETX1; HEL-S-83p; SRPX; SRPX1
UniProt ID: (Human) P78539
Entrez Gene ID: (Human) 8406
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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