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Invitrogen
SRPX Polyclonal Antibody
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FIGURE: 1 / 2
SRPX Antibody (PA5-98176) in IHC (P)
Immunohistochemical analysis of SRPX in paraffin embedded human heart tissue using a SRPX polyclonal antibody (Product # PA5-98176) at a dilution of 1:600. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected... View More
Product Details
PA5-98176
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Sushi repeat-containing protein SRPX protein (31-237AA)
Conjugate
Form
Liquid
Concentration
2.63 mg/mL
Amount
263 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a novel protein with short consensus repeats of six cysteines; the protein has three short consensus repeats (SCR), which is a motif of approximately 60 amino acids; epididymis secretory sperm binding protein Li 83p; Sushi repeat-containing protein SRPX; sushi-repeat-containing protein, X chromosome; unnamed protein product
Gene Aliases: DRS; ETX1; HEL-S-83p; SRPX; SRPX1
UniProt ID: (Human) P78539
Entrez Gene ID: (Human) 8406
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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