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SRPX2 Antibody (PA5-90463) in WB
Western blot analysis of SRPX2 in mouse brain. Samples were incubated with SRPX2 Polyclonal antibody (Product # PA5-90463) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 10s.
Product Details
PA5-90463
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 166-465 of human SRPX2 (NP_0552821)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806088
Product Specific Information
Immunogen sequence: DGRWSGGEPV CVDIDPPKIR CPHSREKMAE PEKLTARVYW DPPLVKDSAD GTITRVTLRG PEPGSHFPEG EHVIRYTAYD RAYNRASCKF IVKVQVRRCP TLKPPQHGYL TCTSAGDNYG ATCEYHCDGG YDRQGTPSRV CQSSRQWSGS PPICAPMKIN VNVNSAAGLL DQFYEKQRLL IISAPDPSNR YYKMQISMLQ QSTCGLDLRH VTIIELVGQP PQEVGRIREQ QLSANIIEEL RQFQRLTRSY FNMVLIDKQG IDRDRYMEPV TPEEIFTFID DYLLSNQELT QRREQRDICE; Positive Samples: Mouse brain; Cellular Location: Cell junction, Cell surface, Cytoplasm, synapse
Target Information
Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RP11-524D16__A.1; Sushi repeat-containing protein SRPX2; sushi-repeat containing protein
Gene Aliases: 1110039C07Rik; SRP; SRPUL; Srpx2
UniProt ID: (Mouse) Q8R054
Entrez Gene ID: (Mouse) 68792
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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