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Invitrogen
SRSF11 Polyclonal Antibody
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FIGURE: 1 / 2
SRSF11 Antibody (PA5-101910) in ICC/IF
Immunocytochemistry analysis of SRSF11 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SRSF11 polyclonal antibody (Product # PA5-101910) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-101910
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SRSF11(Accession Q05519), corresponding to amino acid residues E441-D484.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SFRS11.
Target Information
Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns that are required for accurate splice site recognition and the control of alternative splicing. Splicing enhancer elements contain specific binding sites for serine/arginine (SR)-rich splicing factors, which include SC35, 9G8, SRp20 and SF2/ASF. The family of SR factors all contain one or more RNA recognition motifs (RRM) and a SR-rich domain. The SR factor family is not only essential for constitutive splicing, but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. SFRS11 (splicing factor, arginine/serine-rich 11), also known as arginine-rich 54 kDa nuclear protein (p54) or NET2, is a 484 amino acid nuclear protein that colocalizes with spliceosome components and belongs to the splicing factor SR family. SFRS11 may function in pre-mRNA splicing and contains one RRM (RNA recognition motif) domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arginine-rich 54 kDa nuclear protein; p54; Serine/arginine-rich splicing factor 11; SFR11; splicing factor p54; Splicing factor, arginine/serine-rich 11; SR splicing factor 11; unnamed protein product
Gene Aliases: 0610009J05Rik; 2610019N13Rik; BF642805; dJ677H15.2; NET2; p54; SFRS11; SRSF11
UniProt ID: (Human) Q05519
Entrez Gene ID: (Human) 9295, (Mouse) 69207
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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