Immunogen sequence: LKVDNLTYRT SPDSLRRVFE KYGRVGDVYI PR
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
SFRS2 is necessary for the splicing of pre-mRNA. The protein is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. And it interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. It binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3' and can bind to beta-globin mRNA and commit it to the splicing pathway.
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Protein Aliases: MRF-1; myelin regulatory factor 1; Protein PR264; Putative myelin regulatory factor 1; SC-35; Serine/arginine-rich splicing factor 2; SFRS2; Splicing component, 35 kDa; Splicing factor SC35; Splicing factor, arginine/serine-rich 2; splicing factor, arginine/serine-rich 2 (SC-35); SR splicing factor 2
Gene Aliases: D11Wsu175e; MRF-1; PR264; SC-35; SC35; Sfrs10; SFRS2; SFRS2A; SRp30b; SRSF2