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Invitrogen
SRSF4 Polyclonal Antibody
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Product Details
PA5-36366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 100-150 of human SRp75
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 57 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Serine/arginine-rich protein 75 (SRp75) is encoded by the SRSF4 gene. SRp75 belongs to the arginine/serine-rich factor family and likely plays a role in alternative mRNA splicing.The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/ serine (RS)-rich domain. They are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. The majority of SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 are continuously shuttled between the nucleus and the cytoplasm and contribute to mRNA transport. The activity of SR proteins in regulated splicing is antagonized by members of the hnRNP A/B family of proteins, which induce drastic shifts in the selection of splicing sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Pre-mRNA-splicing factor SRP75; Serine/arginine-rich splicing factor 4; Splicing factor, arginine/serine-rich 4; splicing factor, arginine/serine-rich 4 (SRp75); SR splicing factor 4; SRP001LB
Gene Aliases: 5730499P16Rik; AW550192; MNCb-2616; RGD1561347; SFRS4; SRP75; SRSF4
UniProt ID: (Human) Q08170
Entrez Gene ID: (Human) 6429, (Rat) 362612, (Mouse) 57317
RNA splicing, via transesterification reactions
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
mRNA processing
RNA export from nucleus
mRNA export from nucleus
RNA splicing
mRNA 3'-end processing
negative regulation of mRNA splicing, via spliceosome
hematopoietic progenitor cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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