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Invitrogen
SRY Polyclonal Antibody
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FIGURE: 1 / 2
SRY Antibody (PA5-101147) in IHC (P)
Immunohistochemistry analysis of SRY in human ovarian cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SRY polyclonal antibody (Product # PA5-101147) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101147
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SRY(Accession Q05066), corresponding to amino acid residues V60-F110.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SRY.
Target Information
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: essential protein for sex determination in human males; HMG box transcription factor Sry1; HMG box transcription factor Sry3BI; male gonadal sex-determining locus; sex determining region of Chr Y; sex determining region on Y; sex-determining region on Y; Sex-determining region Y protein; Testis determining locus; Testis-determining factor; testis-determining factor on Y
Gene Aliases: SRXX1; SRXY1; SRY; Sry1; Sry3BI; SRYGENE; TDF; TDY
UniProt ID: (Human) Q05066
Entrez Gene ID: (Human) 6736, (Rat) 25221
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
calmodulin binding
DNA-binding transcription factor binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
DNA binding, bending
enzyme binding
sequence-specific DNA binding
protein heterodimerization activity
HMG box transcription factor
regulation of transcription from RNA polymerase II promoter
sex differentiation
positive regulation of gene expression
cell differentiation
male sex determination
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of male gonad development
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription from RNA polymerase II promoter
sex determination
male gonad development
negative regulation of gene expression
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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