The antibody detects endogenous level of total SYT protein.
The transcriptional coactivator SYT (synovial translocation protein) contains a conserved amino terminal SNH domain and a carboxy terminal QPGY domain, which is a functioning transcriptional activating sequence. Synovial sarcoma translocation (SSX) proteins, including SSX1-5, are transcriptional repressors that contain a repressor domain in their carboxy termini. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. The t(x;18) translocation results in the fusion of the amino terminus of SYT to the carboxy terminus of either SSX1 or SSX2; both fusions result in the production of transcriptional activators.
Protein Aliases: MGC116875; Protein SSXT; Protein SYT; synovial sarcoma associated SS18-beta; synovial sarcoma associated SS18-delta; synovial sarcoma associated SS18-gamma; Synovial sarcoma translocated to X chromosome protein; synovial sarcoma translocation; synovial sarcoma translocation, chromosome 18; synovial sarcoma, translocated to X chromosome; Synovial sarcoma-associated Ss18-alpha
Gene Aliases: D130059H17; SS18; SSXT; SYT
Molecular Function: transcription cofactor