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Positive test controls include: Jurkat, LO2, HepG2, 293T. The target is usually found in the following locations: Nucleus.
Immunogen sequence: KFVETPGQKY KETDLLILFK DDYFAKKNEE RKQNKVEAKL RAKQEQEAKQ KLEEDAEMKS LEEKIGCLLK FSGDLDDQTC REDLHILFSN HGEIKWIDFV RGAKEGIILF KEKAKEALGK AKDANNGNLQ LRNKEVTWEV LEGEVEKEAL KKIIEDQQES LNKWKSKGRR FKGKGKGNKA AQPGSGKGKV QFQGKKTKFA SDDEHDEHDE NGATGPVKRA REETDKEEPA SKQQKTENGA GDQ
La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: autoantigen La; La autoantigen; La ribonucleoprotein; La ribonucleoprotein domain family, member 3; lupus La antigen; Lupus La protein; OTTHUMP00000204777; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B (autoantigen La); SS-B; SS-B/La protein
Gene Aliases: La; La/SSB; LARP3; SSB
UniProt ID: (Human) P05455
Entrez Gene ID: (Human) 6741
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