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Bethyl Laboratories
SSB1 Polyclonal Antibody
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FIGURE: 1 / 2
SSB1 Antibody (A301-938A) in IHC (P)
Detection of human and mouse SSB1 by immunohistochemistry. Sample: FFPE sections of human colon carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SSB1 (Product # A301-938A) (Lot 1) used at a dilution of 1:1,000 (1 µg/mL). Detection: DAB.
Product Details
A301-938A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 161 and 211 of Human single-stranded DNA-binding protein 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for human tissues. Epitope retrieval with citrate buffer pH 6.0 is recommended for mouse tissues.
Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSSB1; LP3587; Nucleic acid-binding protein 2; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; single strand DNA-binding protein 1; Single-stranded DNA-binding protein 1; SOSS complex subunit B1; SOSS-B1
Gene Aliases: 2610036N15Rik; hSSB1; LP3587; NABP2; OBFC2B; SOSS-B1; SSB1
UniProt ID: (Human) Q9BQ15, (Mouse) Q8R2Y9
Entrez Gene ID: (Human) 79035, (Mouse) 69917
double-strand break repair via homologous recombination
DNA repair
cellular response to DNA damage stimulus
mitotic cell cycle checkpoint
response to ionizing radiation
snRNA transcription from RNA polymerase II promoter
regulation of telomerase activity
establishment of protein localization to telomere
positive regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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