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Invitrogen
SSH1 Polyclonal Antibody
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FIGURE: 1 / 1
SSH1 Antibody (PA5-143765) in WB
Western blot of SSH1 in human recombinant SSH1L untreated (lanes 1 & 3) or treated with lambda phosphatase (lanes 2 & 4) and rat PC12 cells unstimulated (lanes 5 & 7) or stimulated with calyculin A (lanes 6 & 8). The blots were probed with SSH1 polyclonal antibody (Product # PA5-143765) (lanes 1, 2, 5, & 6) or Phospho-SSH1 (Ser978) polyclonal antibody (Product # PA5-143766) (lanes 3, 4, 7, & 8).
Product Details
PA5-143765
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human SSH1L. This sequence has 100% homology with similar regions of mouse and bovine SSH1L, and has low homology to SSH2L and SSH3L.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects a 150 kDa* protein corresponding to the molecular mass of SSH1L on SDS-PAGE immunoblots of PC12 cells.
Target Information
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSSH-1L; Protein phosphatase Slingshot homolog 1; slingshot 1; slingshot 1L; slingshot homolog 1; slingshot-like 1; SSH-1L; SSH-like protein 1; unnamed protein product
Gene Aliases: AW551225; Gm1394; Gm1395; KIAA1298; mSSH-1L; SSH-1; SSH1; SSH1L
UniProt ID: (Human) Q8WYL5, (Mouse) Q76I79
Entrez Gene ID: (Human) 54434, (Mouse) 231637, (Rat) 304580
cell morphogenesis
protein dephosphorylation
actin cytoskeleton organization
negative regulation of actin filament polymerization
positive regulation of synaptic plasticity
regulation of protein metabolic process
cellular response to ATP
excitatory chemical synaptic transmission
positive regulation of AMPA glutamate receptor clustering
positive regulation of vascular associated smooth muscle cell migration
positive regulation of excitatory postsynaptic potential
regulation of actin polymerization or depolymerization
regulation of lamellipodium assembly
dephosphorylation
regulation of cellular protein metabolic process
regulation of axonogenesis
peptidyl-tyrosine dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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