PA3-111 detects the Somatostatin Receptor 4 in human and mouse samples.
PA3-111 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR4 transfected HEK-293 cells this antibody detects a ~40-50 kDa protein representing SSTR4.
The PA3-111 immunogen is a synthetic peptide corresponding to residues C(366) Q Q E A L Q P E P G R K R I P L T R T T T F(388) of human SSTR4.
SSTR4 has been reported to be expressed in brain, gastrointestinal tract, pancreas, and prostate tissues. No ESTs have been identified.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G-protein coupled receptor; Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R; SSTR4
Gene Aliases: Smstr4; SS-4-R; SS4-R; SS4R; sst4; SSTR4