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Product Details
H00026228-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STAP1 (NP_036240.1, 1 a.a. approximately 295 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR GTTLFFYTDK KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ LKTENTESGE EWRGFILTVT ELSVPQNVSL LPGQVIKLHE VLEREKKRRI ETEQSTSVEK EKEPTEDYVD VLNPMPACFY TVSRKEATEM LQKNPSLGNM ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL EKPVTLPNLF SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA
Target Information
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCR downstream signaling 1; BCR downstream-signaling protein 1; Docking protein BRDG1; Signal-transducing adaptor protein 1; STAP-1; Stem cell adaptor protein 1; stem cell adaptor protein STAP-1
Gene Aliases: AI586015; BRDG1; STAP-1; STAP1
UniProt ID: (Human) Q9ULZ2, (Mouse) Q9JM90
Entrez Gene ID: (Human) 26228, (Mouse) 56792
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of gene expression
negative regulation of macrophage chemotaxis
negative regulation of phosphorylation
positive regulation of B cell receptor signaling pathway
positive regulation of phagocytosis, engulfment
cellular response to lipopolysaccharide
negative regulation of ruffle assembly
negative regulation of macrophage colony-stimulating factor signaling pathway
positive regulation of microglial cell activation
positive regulation of non-membrane spanning protein tyrosine kinase activity
negative regulation of microglial cell migration
positive regulation of microglial cell mediated cytotoxicity
positive regulation of actin cytoskeleton reorganization
positive regulation of signal transduction
myeloid cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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