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Invitrogen
STAR Polyclonal Antibody
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FIGURE: 1 / 5
STAR Antibody (PA5-21687) in ICC/IF
STAR Polyclonal Antibody detects StAR protein at mitochondria by immunofluorescent analysis. Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: StAR protein stained by STAR Polyclonal Antibody (Product # PA5-21687) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
PA5-21687
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Chicken,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human StAR. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: K562, mouse kidney, STAR-transfected 293T.
Predicted reactivity: Mouse (90%), Rat (89%), Dog (93%), Cat (89%), Pig (90%), Sheep (86%), Rhesus Monkey (98%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cholesterol trafficker; Luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP
Gene Aliases: AV363654; D8Ertd419e; STAR; STARD1
UniProt ID: (Human) P49675, (Mouse) P51557
Entrez Gene ID: (Human) 6770, (Mouse) 20845
steroid biosynthetic process
bile acid biosynthetic process
estrogen biosynthetic process
transport
lipid transport
glucocorticoid metabolic process
positive regulation of gene expression
cellular response to interferon-alpha
negative regulation of neuron apoptotic process
cellular lipid metabolic process
regulation of neuronal synaptic plasticity
positive regulation of neurogenesis
regulation of steroid biosynthetic process
C21-steroid hormone biosynthetic process
progesterone biosynthetic process
brain development
response to nutrient
cholesterol metabolic process
male gonad development
response to herbicide
response to ionizing radiation
response to lead ion
response to activity
diterpenoid metabolic process
insecticide metabolic process
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
intracellular cholesterol transport
cellular response to insulin stimulus
response to nicotine
response to drug
response to hydrogen peroxide
circadian sleep/wake cycle, REM sleep
response to estrogen
response to leptin
cellular response to fibroblast growth factor stimulus
response to ethanol
response to corticosterone
response to fungicide
testosterone biosynthetic process
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to cadmium ion
cellular response to alkaloid
cellular response to cAMP
cellular response to glucose stimulus
cellular response to interferon-gamma
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
cellular response to growth hormone stimulus
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
cellular response to epinephrine stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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