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Invitrogen
STAR Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95765
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.56 mg/mL
Amount
256 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: K-562, Mouse ovary, Rat testis; Cellular Location: Mitochondrion
Immunogen sequence: EETLYSDQEL AYLQQGEEAM QKALGILSNQ EGWKKESQQD NGDKVMSKVV PDVGKVFRLE VVVDQPMERL YEELVERMEA MGEWNPNVKE IKVLQKIGKD TFITHELAAE AAGNLVGPRD FVSVRCAKRR GSTCVLAGMA TDFGNMPEQK GVIRAEHGPT CMVLHPLAGS PSKTKLTWLL SIDLKGWLPK SIINQVLSQT QVDFANHLRK RLESHPASEA RC
Target Information
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cholesterol trafficker; luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; STAR; StAR related lipid transfer (START) domain containing 1; stARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; testis secretory sperm-binding protein Li 241mP; unnamed protein product
Gene Aliases: D8Ertd419e; STARD1
UniProt ID: (Human) P49675, (Mouse) P51557, (Rat) P97826
Entrez Gene ID: (Human) 6770, (Mouse) 20845, (Rat) 25557
steroid biosynthetic process
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
steroid metabolic process
cholesterol metabolic process
intracellular cholesterol transport
regulation of steroid biosynthetic process
positive regulation of bile acid biosynthetic process
lipid metabolic process
bile acid biosynthetic process
estrogen biosynthetic process
response to nutrient
circadian rhythm
glucocorticoid metabolic process
male gonad development
response to xenobiotic stimulus
response to herbicide
response to toxic substance
response to ionizing radiation
response to lead ion
positive regulation of gene expression
response to activity
response to insecticide
response to nutrient levels
response to retinoic acid
cellular response to insulin stimulus
response to gonadotropin
response to nicotine
cellular response to interferon-alpha
response to hydrogen peroxide
response to peptide hormone
negative regulation of neuron apoptotic process
response to estrogen
response to leptin
cellular response to fibroblast growth factor stimulus
response to ethanol
regulation of neuronal synaptic plasticity
response to steroid hormone
positive regulation of neurogenesis
response to corticosterone
response to fungicide
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to metal ion
cellular response to cadmium ion
cellular response to alkaloid
cellular response to cAMP
cellular response to glucose stimulus
cellular response to interferon-gamma
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
cellular response to growth hormone stimulus
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
cellular response to epinephrine stimulus
response to benzoic acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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