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Invitrogen
STAT1 Polyclonal Antibody
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Product Details
PA5-68786
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of rat STAT1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Dog: 92%; Guinea Pig: 85%; Horse: 92%; Human: 85%; Mouse: 100%; Rabbit: 92%; Rat: 93%
Target Information
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686B04100; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1-alpha/beta; STAT; STAT 1; STAT-1; stat1 alpha
Gene Aliases: DD6G4-4
Entrez Gene ID: (Rat) 25124
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
tumor necrosis factor receptor binding
enzyme binding
CCR5 chemokine receptor binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
protein phosphatase 2A binding
DNA-binding transcription factor
negative regulation of endothelial cell proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
activation of cysteine-type endopeptidase activity involved in apoptotic process
JAK-STAT cascade
response to nutrient
blood circulation
positive regulation of cell proliferation
response to mechanical stimulus
response to bacterium
response to organic cyclic compound
negative regulation of angiogenesis
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
cellular response to insulin stimulus
tumor necrosis factor-mediated signaling pathway
response to cytokine
negative regulation of macrophage fusion
cellular response to interferon-beta
response to drug
response to hydrogen peroxide
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
response to peptide hormone
endothelial cell migration
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation by virus of viral protein levels in host cell
positive regulation of smooth muscle cell proliferation
response to cAMP
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
renal tubule development
cellular response to lipopolysaccharide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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