Search

  • Order Status
  • Quick Order
  • Promos

Bioss

STAT1 p84/p91 Polyclonal Antibody

View all (2) STAT1 alpha/beta antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

BS-9584R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human STAT1 p84/p91.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; transcription factor; Transcription factor ISGF-3 components p91/p84; transcription factor; 91 kDa; unnamed protein product

View more View less

Gene Aliases: 2010005J02Rik; AA408197; CANDF7; DD6G4-4; IMD31A; IMD31B; IMD31C; ISGF-3; STAT1; STAT91

View more View less

UniProt ID: (Human) P42224

View more View less

Entrez Gene ID: (Human) 6772, (Mouse) 20846, (Rat) 25124

View more View less

Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcription coactivator binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding tumor necrosis factor receptor binding protein binding enzyme binding CCR5 chemokine receptor binding histone acetyltransferase binding histone binding identical protein binding protein homodimerization activity sequence-specific DNA binding ubiquitin-like protein ligase binding cadherin binding protein phosphatase 2A binding promoter-specific chromatin binding transcription factor activity, RNA polymerase II core promoter sequence-specific signal transducer activity DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of endothelial cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of defense response to virus by host negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade response to nutrient blood circulation positive regulation of cell proliferation response to xenobiotic stimulus response to mechanical stimulus negative regulation of angiogenesis positive regulation of interferon-alpha production cellular response to insulin stimulus tumor necrosis factor-mediated signaling pathway response to cytokine response to interferon-gamma response to interferon-beta cellular response to interferon-beta interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway regulation of cell proliferation response to hydrogen peroxide regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to peptide hormone endothelial cell migration positive regulation of nitric oxide biosynthetic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade negative regulation by virus of viral protein levels in host cell positive regulation of smooth muscle cell proliferation negative regulation of developmental process response to cAMP defense response to virus interferon-gamma-mediated signaling pathway type I interferon signaling pathway renal tubule development interleukin-27-mediated signaling pathway cellular response to cytokine stimulus cellular response to interferon-gamma metanephric mesenchymal cell proliferation involved in metanephros development metanephric mesenchymal cell differentiation negative regulation of metanephric nephron tubule epithelial cell differentiation receptor signaling pathway via STAT transcription, DNA-templated transcription from RNA polymerase II promoter activation of cysteine-type endopeptidase activity involved in apoptotic process response to bacterium cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide negative regulation of macrophage fusion response to drug response to exogenous dsRNA cellular response to lipopolysaccharide response to organic cyclic compound
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support