Proteintech

STAT5A Polyclonal Antibody

18 References
View all (91) STAT5 alpha antibodies

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STAT5A Polyclonal Antibody

Product Details

13179-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 13 publications 13 publications

Immunohistochemistry (IHC)

-
View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells
-

Immunoprecipitation (IP)

0.5-4.0 µg
-

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STAT5A Fusion Protein Ag3846 (445-794 aa encoded by BC027036)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human STAT5A.

Immunogen sequence: ESQFSVGSN ELVFQVKTLS LPVVVIVHGS QDHNATATVL WDNAFAEPGR VPFAVPDKVL WPQLCEALNM KFKAEVQSNR GLTKENLVFL AQKLFNNSSS HLEDYSGLSV SWSQFNRENL PGWNYTFWQW FDGVMEVLKK HHKPHWNDGA ILGFVNKQQA HDLLINKPDG TFLLRFSDSE IGGITIAWKF DSPERNLWNL KPFTTRDFSI RSLADRLGDL SYLIYVFPDR PKDEVFSKYY TPVLAKAVDG YVKPQIKQVV PEFVNASADA GGSSATYMDQ APSPAVCPQA PYNMYPQNPD HVLDQDGEFD LDETMDVARH VEELLRRPMD SLDSRLSPPA GLFTSARGSL S (445-794 aa encoded by BC027036)

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Mammary gland factor; mammary gland factor STAT5A; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; STAT; STAT5B

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Gene Aliases: AA959963; MGF; Mpf; STAT5; STAT5A

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UniProt ID: (Human) P42229, (Rat) Q62771, (Mouse) P42230

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Entrez Gene ID: (Human) 6776, (Rat) 24918, (Mouse) 20850

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding protein tyrosine kinase activity signal transducer activity protein binding RNA polymerase II core promoter sequence-specific DNA binding double-stranded DNA binding protein phosphatase binding sequence-specific DNA binding DNA-binding transcription factor
Process(es)
allantoin metabolic process positive regulation of endothelial cell proliferation citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated regulation of transcription from RNA polymerase II promoter isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process JAK-STAT cascade lactation peptidyl-tyrosine phosphorylation taurine metabolic process prolactin signaling pathway regulation of multicellular organism growth positive regulation of blood vessel endothelial cell migration creatinine metabolic process JAK-STAT cascade involved in growth hormone signaling pathway luteinization natural killer cell differentiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter signal transduction female pregnancy positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway lipid storage regulation of cell adhesion regulation of epithelial cell differentiation mammary gland development response to nutrient levels positive regulation of natural killer cell differentiation negative regulation of mast cell apoptotic process T cell differentiation in thymus positive regulation of multicellular organism growth positive regulation of activated T cell proliferation T cell homeostasis negative regulation of apoptotic process response to peptide hormone positive regulation of interleukin-2 biosynthetic process response to ethanol positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development multicellular organismal reproductive process positive regulation of inflammatory response mammary gland involution positive regulation of mast cell differentiation prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus
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