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Proteintech
STC1 Polyclonal Antibody
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Product Details
20621-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STC1 Fusion Protein Ag14697 (98-247 aa encoded by BC029044)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CIANGVTSK VFLAIRRCST FQRMIAEVQE ECYSKLNVCS IAKRNPEAIT EVVQLPNHFS NRYYNRLVRS LLECDEDTVS TIRDSLMEKI GPNMASLFHI LQTDHCAQTH PRADFNRRRT NEPQKLKVLL RNLRGEEDSP SHIKRTSHES A (98-247 aa encoded by BC029044)
Target Information
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Stanniocalcin-1; STC-1
Gene Aliases: STC; STC1
UniProt ID: (Human) P52823, (Mouse) O55183, (Rat) P97574
Entrez Gene ID: (Human) 6781, (Mouse) 20855, (Rat) 81801
ossification
endothelial cell morphogenesis
growth plate cartilage axis specification
cellular calcium ion homeostasis
embryo implantation
negative regulation of endothelial cell migration
negative regulation of cell migration
response to vitamin D
chondrocyte proliferation
regulation of anion transport
decidualization
negative regulation of calcium ion transport
bone development
cellular response to cAMP
cellular response to glucocorticoid stimulus
cellular response to hypoxia
regulation of cardiac muscle cell contraction
positive regulation of calcium ion import
negative regulation of renal phosphate excretion
cellular monovalent inorganic anion homeostasis
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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