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Product Details
PA5-54924
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (IHC) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein corresponding to Human STC1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2648009 |
Product Specific Information
Immunogen sequence: EQNDSVSPRK SRVAAQNSAE VVRCLNSALQ VGCGAFACLE NSTCDTDGMY DICKSFLYSA AKFDTQGKAF VKESL
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Stanniocalcin-1; STC-1
Gene Aliases: STC; STC1
UniProt ID: (Human) P52823
Entrez Gene ID: (Human) 6781
Molecular Function:
peptide hormone
intercellular signal molecule
ossification
endothelial cell morphogenesis
growth plate cartilage axis specification
cellular calcium ion homeostasis
embryo implantation
negative regulation of endothelial cell migration
negative regulation of cell migration
response to vitamin D
chondrocyte proliferation
regulation of anion transport
decidualization
negative regulation of calcium ion transport
bone development
cellular response to cAMP
cellular response to glucocorticoid stimulus
cellular response to hypoxia
regulation of cardiac muscle cell contraction
positive regulation of calcium ion import
negative regulation of renal phosphate excretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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