Immunogen sequence: EQNDSVSPRK SRVAAQNSAE VVRCLNSALQ VGCGAFACLE NSTCDTDGMY DICKSFLYSA AKFDTQGKAF VKESL
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
Protein Aliases: Stanniocalcin-1; STC-1
Gene Aliases: STC; STC1
UniProt ID: (Human) P52823
Entrez Gene ID: (Human) 6781