The six-transmembrane epithelial antigen of prostate 4 (STEAP4) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP3), STEAP4 promotes both iron and copper reduction. STEAP4 is highly expressed in placenta, lung, heart and prostate tissues, and overexpressed in prostate cancer cells compared to normal prostate cells. Overexpression of STEAP4 in prostate cells significantly increases cell growth and colony formation, suggesting STEAP4 may have a role in cell proliferation and prostate cancer progression.
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Protein Aliases: Ab1-219; DKFZp666D049; dudulin 4; Dudulin-4; FLJ23153; Metalloreductase STEAP4; six transmembrane prostate protein 2; Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; STEAP family member 4; Tnfa-induced adipose-related protein; Tumor necrosis factor, alpha-induced protein 9; Tumor necrosis factor-alpha-induced adipose-related protein; tumor necrosis-alpha-induced adipose-related protein
Gene Aliases: 1110021O17Rik; AI481214; STAMP2; STEAP4; TIARP; TNFAIP9